Contributions
Abstract: 34
Type: Hot Topic
Abstract Category: N/A
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The initial phases of the disease are characterized by inflammatory lesions initiated by the adaptive immune system. While the phenotype, function and regulation of CNS specific T cells has been well characterized in experimental models auf CNS autoimmunity, less is known about the generation, recruitment, and effector functions of T cells in human MS. In particular, the interplay of autoreactive T cells with B cells has become an increasingly appreciated topic with the introduction of highly efficient B cell directed therapies in MS. Here, we will discuss aspects of B cells as antigen presenting cells, sources of inflammatory cytokines, and precursors of antibody producing cells. Finally, the concept of compartmentalized inflammation within the CNS compartment (disconnected from the systemic immune compartment), which might explain much of the later phases of MS, will be addressed. Some novel and surprising experimental findings, which illustrate how foci of chronic inflammation might build up in the meninges will be presented.
In summary, this presentation will give an overview over novel aspects of the adaptive immune response in MS during early and late phases of the disease with the aim of fostering the understanding of the mode of action of current MS therapies and illustrating unmet needs that should be addressed by novel therapeutic approaches.
Disclosure: Nothing to disclose
Abstract: 34
Type: Hot Topic
Abstract Category: N/A
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The initial phases of the disease are characterized by inflammatory lesions initiated by the adaptive immune system. While the phenotype, function and regulation of CNS specific T cells has been well characterized in experimental models auf CNS autoimmunity, less is known about the generation, recruitment, and effector functions of T cells in human MS. In particular, the interplay of autoreactive T cells with B cells has become an increasingly appreciated topic with the introduction of highly efficient B cell directed therapies in MS. Here, we will discuss aspects of B cells as antigen presenting cells, sources of inflammatory cytokines, and precursors of antibody producing cells. Finally, the concept of compartmentalized inflammation within the CNS compartment (disconnected from the systemic immune compartment), which might explain much of the later phases of MS, will be addressed. Some novel and surprising experimental findings, which illustrate how foci of chronic inflammation might build up in the meninges will be presented.
In summary, this presentation will give an overview over novel aspects of the adaptive immune response in MS during early and late phases of the disease with the aim of fostering the understanding of the mode of action of current MS therapies and illustrating unmet needs that should be addressed by novel therapeutic approaches.
Disclosure: Nothing to disclose