Contributions
Abstract: EP1735
Type: Poster Sessions
Abstract Category: Therapy - Others
Background: High-dose IV methylprednisolone is the first-line treatment for acute relapses. Women with multiple sclerosis (MS) experience an increased risk of relapse during the postpartum period. Previously we have demonstrated that little amounts of methylprednisolone transfer into breast milk 2 hours after end of infusion. There is only limited data into the levels of concentration in breast milk and blood during and shortly after IV pulse methylprednisolone therapy.
Objectives: The study aimed to determine the transfer of methylprednisolone into human milk and serum during and shortly after infusion in breastfeeding MS patients.
Methods: IV methylprednisolone pulse therapy was given to 12 lactating MS patients. Breast milk and blood samples were obtained just before infusion, 30 minutes into infusion, straight after infusion and 1 hour thereafter.
Methylprednisolone concentrations were quantified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)
Results: MS patients aged (25.6 ± 6.1), weight in kg (71.4 ± 6.4), duration of MS in years (3.88 ± 2.2), and an EDSS (1.5 ± 0.8). Infants aged (months) (7.66 ± 4.0) and weighed (kg) (7.8 ± 2.6).
The methylprednisolone concentrations in milk were below detection limits just before infusion. Concentrations at 30 minutes into infusion were 2.9 µg/ml in milk and 6.1 µg/ml in serum. Maximum levels measured straight after infusion were 3.2 µg/ml in milk and 8.35 µg/ml in serum. Blood and milk concentration levels started to drop 1 hour after infusion.
Conclusion: Relatively small methylprednisolone concentration levels were transferred into breast milk during infusion. Results demonstrate that the relative infant dose (RID) of the weight-adjusted maternal dose was lower than the generally accepted RID of 10%. Nevertheless, infant exposure should be taken into account during and shortly after the infusion and mothers are recommended to wait 2 to 4 hours to breastfeed to further limit infant exposure.
Disclosure: Authors has nothing to disclose.
Abstract: EP1735
Type: Poster Sessions
Abstract Category: Therapy - Others
Background: High-dose IV methylprednisolone is the first-line treatment for acute relapses. Women with multiple sclerosis (MS) experience an increased risk of relapse during the postpartum period. Previously we have demonstrated that little amounts of methylprednisolone transfer into breast milk 2 hours after end of infusion. There is only limited data into the levels of concentration in breast milk and blood during and shortly after IV pulse methylprednisolone therapy.
Objectives: The study aimed to determine the transfer of methylprednisolone into human milk and serum during and shortly after infusion in breastfeeding MS patients.
Methods: IV methylprednisolone pulse therapy was given to 12 lactating MS patients. Breast milk and blood samples were obtained just before infusion, 30 minutes into infusion, straight after infusion and 1 hour thereafter.
Methylprednisolone concentrations were quantified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)
Results: MS patients aged (25.6 ± 6.1), weight in kg (71.4 ± 6.4), duration of MS in years (3.88 ± 2.2), and an EDSS (1.5 ± 0.8). Infants aged (months) (7.66 ± 4.0) and weighed (kg) (7.8 ± 2.6).
The methylprednisolone concentrations in milk were below detection limits just before infusion. Concentrations at 30 minutes into infusion were 2.9 µg/ml in milk and 6.1 µg/ml in serum. Maximum levels measured straight after infusion were 3.2 µg/ml in milk and 8.35 µg/ml in serum. Blood and milk concentration levels started to drop 1 hour after infusion.
Conclusion: Relatively small methylprednisolone concentration levels were transferred into breast milk during infusion. Results demonstrate that the relative infant dose (RID) of the weight-adjusted maternal dose was lower than the generally accepted RID of 10%. Nevertheless, infant exposure should be taken into account during and shortly after the infusion and mothers are recommended to wait 2 to 4 hours to breastfeed to further limit infant exposure.
Disclosure: Authors has nothing to disclose.