ECTRIMS eLearning

A case of immune-mediated encephalitis related to daclizumab therapy
Author(s): ,
M. Devlin
Affiliations:
Department of Neurology, Princess Alexandra Hospital, Brisbane
,
A. Swayne
Affiliations:
Department of Neurology, Princess Alexandra Hospital, Brisbane; Mater Centre for Neuroscience, Mater Hospital Brisbane, South Brisbane; University of Queensland
,
C. O`Gorman
Affiliations:
Department of Neurology, Princess Alexandra Hospital, Brisbane
,
M. Newman
Affiliations:
Department of Immunology, Princess Alexandra Hospital
,
H. Brown
Affiliations:
Department of Neurology, Princess Alexandra Hospital, Brisbane
,
T. Robertson
Affiliations:
Anatomical Pathology, Pathology Queensland, Brisbane, QLD, Australia
,
C. Airey
Affiliations:
Department of Neurology, Princess Alexandra Hospital, Brisbane
S. Blum
Affiliations:
Department of Neurology, Princess Alexandra Hospital, Brisbane; Mater Centre for Neuroscience, Mater Hospital Brisbane, South Brisbane; University of Queensland
ECTRIMS Learn. Blum S. 10/10/18; 229509; EP1672
Stefan Blum
Stefan Blum
Contributions
Abstract

Abstract: EP1672

Type: Poster Sessions

Abstract Category: Therapy - Risk management for disease modifying treatments

This report will detail a case of immune-mediated encephalitis in the context of daclizumab therapy. Daclizumab is a humanised monoclonal antibody which, prior to its recent worldwide withdrawal due to safety concerns, was utilised as a disease modifying therapy in relapsing-remitting multiple sclerosis. The withdrawal of this therapy was prompted by concerns over twelve cases of serious immune-mediated adverse reactions in the central nervous system. We report an additional case, including clinical data and results of neuroimaging, CSF examination and brain biopsy
Disclosure: For all authors: Nil to declare.

Abstract: EP1672

Type: Poster Sessions

Abstract Category: Therapy - Risk management for disease modifying treatments

This report will detail a case of immune-mediated encephalitis in the context of daclizumab therapy. Daclizumab is a humanised monoclonal antibody which, prior to its recent worldwide withdrawal due to safety concerns, was utilised as a disease modifying therapy in relapsing-remitting multiple sclerosis. The withdrawal of this therapy was prompted by concerns over twelve cases of serious immune-mediated adverse reactions in the central nervous system. We report an additional case, including clinical data and results of neuroimaging, CSF examination and brain biopsy
Disclosure: For all authors: Nil to declare.

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