Contributions
Abstract: EP1566
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Biomarkers
Introduction: Neurodegeneration (ND) occurs early in multiple sclerosis (MS), and caused clinical deterioration and disability. Biomarkers reflecting this phenomena, such as neurofilament light chain (NF-L), tau and β-amyloid (Aβ), could be measured easily in the cerebrospinal fluid (CSF).
Aim: To evaluate if CSF biomarkers of neurodegeneration predict early MS disability.
Methods: CSF NF-L, Aβ and tau levels were determined with commercial enzyme-linked immunosorbent assay in 45 newly-diagnosed MS patients (30 females). Baseline disease-courses were: three radiological (RIS) and 15 clinical isolated syndrome (CIS), 24 relapsing-remitting (RR) and 3 primary of secondary progressive (PR)-MS. Our disability outcome was the MS severity score (MSSS) at the last follow up (minimum 1 year after disease onset). We estimated differences between CSF biomarkers in baseline MS courses and disability with ANOVA.
Results: First, only CSF NF-L differed significantly among MS courses (p=0.004). In fact RIS showed the lowest levels (CSF NF-L mean 206 ng/ml ± standard deviation 220) if compared to CIS (1209±509), RR (1616±741), and PR-MS (1714±27). On contrast, none of the CSF biomarkers was related to MSSS at last follow up. Of note, we excluded a correlation among tau or Aβ with NF-L in the CSF.
Conclusions:
· NF-L are the unique biomarker of neurodegeneration related to MS forms. Their levels increased progressively with MS-course severity reflecting the higher axonal damage in PR-MS.
· CSF NF-L, Aβ and tau failed to predict early MS disability: short-term outcome could not reflect the natural disease history.
Disclosure: Vecchio D: received a Merck Serono fellowship,
Crespi I : nothing to disclose,
Clemente N : nothing to disclose,
Virgilio E : nothing to disclose,
Chiocchetti A : nothing to disclose,
Naldi P : nothing to disclose,
Bellomo G : nothing to disclose,
Cantello R : nothing to disclose,
Comi C: nothing to disclose
Abstract: EP1566
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Biomarkers
Introduction: Neurodegeneration (ND) occurs early in multiple sclerosis (MS), and caused clinical deterioration and disability. Biomarkers reflecting this phenomena, such as neurofilament light chain (NF-L), tau and β-amyloid (Aβ), could be measured easily in the cerebrospinal fluid (CSF).
Aim: To evaluate if CSF biomarkers of neurodegeneration predict early MS disability.
Methods: CSF NF-L, Aβ and tau levels were determined with commercial enzyme-linked immunosorbent assay in 45 newly-diagnosed MS patients (30 females). Baseline disease-courses were: three radiological (RIS) and 15 clinical isolated syndrome (CIS), 24 relapsing-remitting (RR) and 3 primary of secondary progressive (PR)-MS. Our disability outcome was the MS severity score (MSSS) at the last follow up (minimum 1 year after disease onset). We estimated differences between CSF biomarkers in baseline MS courses and disability with ANOVA.
Results: First, only CSF NF-L differed significantly among MS courses (p=0.004). In fact RIS showed the lowest levels (CSF NF-L mean 206 ng/ml ± standard deviation 220) if compared to CIS (1209±509), RR (1616±741), and PR-MS (1714±27). On contrast, none of the CSF biomarkers was related to MSSS at last follow up. Of note, we excluded a correlation among tau or Aβ with NF-L in the CSF.
Conclusions:
· NF-L are the unique biomarker of neurodegeneration related to MS forms. Their levels increased progressively with MS-course severity reflecting the higher axonal damage in PR-MS.
· CSF NF-L, Aβ and tau failed to predict early MS disability: short-term outcome could not reflect the natural disease history.
Disclosure: Vecchio D: received a Merck Serono fellowship,
Crespi I : nothing to disclose,
Clemente N : nothing to disclose,
Virgilio E : nothing to disclose,
Chiocchetti A : nothing to disclose,
Naldi P : nothing to disclose,
Bellomo G : nothing to disclose,
Cantello R : nothing to disclose,
Comi C: nothing to disclose