Contributions
Abstract: EP1561
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Biomarkers
Background: The development of new biomarkers for multiple sclerosis is crucial to improve our ability to predict disease progression and disability. The aim of this study was to study the potential role of optic nerve diameter measurement using ultrasound as a marker of axonal loss, to compare it to optical coherence tomography as a standard biomarker and to elaborate its role in early detection of disability in patients with relapsing remitting multiple sclerosis (RRMS).
Methods: Forty nine patients with relapsing remitting multiple sclerosis (RRMS) with or without history of unilateral optic neuritis were studied for optic nerve sheath diameter (ONSD) using transorbital sonography; retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness measurement using optical coherence tomography (OCT). Age and sex matched healthy controls were recruited as a control group.
Results: RNFL and GCC were significantly thinner in patients group whether in affected eyes (p < 0.001) or unaffected eyes (p < 0.001). There was no significant statistical difference neither in the optic nerve diameter nor in the optic nerve sheath diameter (ONSD) between affected (p = 0.319, 0.760) respectively) and unaffected eyes (p = 0.396, 0.335 respectively) of both groups. However, patients with EDSS > 2 had significantly lower ONSD, RNFL thickness and GCC (p = 0.035, p = 0.039, p < 0.001 respectively) as compared to patients with EDSS ≤ 2.
Conclusion: Transorbital sonographic measurement of optic nerve sheath diameter (ONSD) is a potentially valuable marker for early detection of disability in patients with relapsing remitting multiple sclerosis.
Key words: optic nerve sheath diameter, multiple sclerosis, optic coherence tomography
Disclosure: Noha Abo Koraysha: nothing to disclose
Nirmeen Kishk : nothing to disclose
Amr Hassan : nothing to disclose
Nehal M El Gendy : nothing to disclose
Hatem S Shehata : nothing to disclose
Nevin M Shalaby : nothing to disclose
Salsabil Abo Al-Azayem : nothing to disclose
Abstract: EP1561
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Biomarkers
Background: The development of new biomarkers for multiple sclerosis is crucial to improve our ability to predict disease progression and disability. The aim of this study was to study the potential role of optic nerve diameter measurement using ultrasound as a marker of axonal loss, to compare it to optical coherence tomography as a standard biomarker and to elaborate its role in early detection of disability in patients with relapsing remitting multiple sclerosis (RRMS).
Methods: Forty nine patients with relapsing remitting multiple sclerosis (RRMS) with or without history of unilateral optic neuritis were studied for optic nerve sheath diameter (ONSD) using transorbital sonography; retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness measurement using optical coherence tomography (OCT). Age and sex matched healthy controls were recruited as a control group.
Results: RNFL and GCC were significantly thinner in patients group whether in affected eyes (p < 0.001) or unaffected eyes (p < 0.001). There was no significant statistical difference neither in the optic nerve diameter nor in the optic nerve sheath diameter (ONSD) between affected (p = 0.319, 0.760) respectively) and unaffected eyes (p = 0.396, 0.335 respectively) of both groups. However, patients with EDSS > 2 had significantly lower ONSD, RNFL thickness and GCC (p = 0.035, p = 0.039, p < 0.001 respectively) as compared to patients with EDSS ≤ 2.
Conclusion: Transorbital sonographic measurement of optic nerve sheath diameter (ONSD) is a potentially valuable marker for early detection of disability in patients with relapsing remitting multiple sclerosis.
Key words: optic nerve sheath diameter, multiple sclerosis, optic coherence tomography
Disclosure: Noha Abo Koraysha: nothing to disclose
Nirmeen Kishk : nothing to disclose
Amr Hassan : nothing to disclose
Nehal M El Gendy : nothing to disclose
Hatem S Shehata : nothing to disclose
Nevin M Shalaby : nothing to disclose
Salsabil Abo Al-Azayem : nothing to disclose