Contributions
Abstract: EP1541
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Cognitive impairment can be one of the major deficits multiple sclerosis (MS) patients are suffering from. Still cognitive deficits are not frequently examined and diagnosed due to the limited time of Neurologists and Neuropsychologists. It is well known that even mild cognitive deficits can lead to a loss in quality of life as patients complain about problems in their daily life. Therefore we tested if impaired natural viewing behaviour reflects cognitive impairment in MS. We used the BOiS - Berlin Object in Scene Database (Mohr et al., 2016) which includes photographs of naturalistic scenes with a typical object at two different locations - expected versus unexpected location - and one where the target object is absent. 105 of those photographs were rated into three different categories depending on the difficulty. We measured the reaction times and used eye-tracking in 92 subjects (53 patients with relapse-remitting MS and with progressive multiple sclerosis and 39 healthy control subjects). Reaction times differed between the patients and healthy controls as well between the different difficulty and object location (expected, unexpected and missing). Furthermore, eye-tracking of natural viewing behaviour differentiated between MS patients and healthy subjects and was linked to cognitive impairment. Natural viewing behaviour as measured with eye-tracking can therefore be used as a predictive tool to evaluate which MS patients should undergo a detailed neuropsychological examination.
Disclosure: Johannes Gehrig was supported by travel grant from Novartis. Yavor Yalachkov was supported by travel grants from Novartis and Genzyme and received honoraria for active participation in advisory boards as well as speaking honoraria by Genzyme and Roche. Christian Förch received speaking honoraria and honoraria for active participation in advisory boards from TEVA, Roche, and Genzyme.
Abstract: EP1541
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Cognitive impairment can be one of the major deficits multiple sclerosis (MS) patients are suffering from. Still cognitive deficits are not frequently examined and diagnosed due to the limited time of Neurologists and Neuropsychologists. It is well known that even mild cognitive deficits can lead to a loss in quality of life as patients complain about problems in their daily life. Therefore we tested if impaired natural viewing behaviour reflects cognitive impairment in MS. We used the BOiS - Berlin Object in Scene Database (Mohr et al., 2016) which includes photographs of naturalistic scenes with a typical object at two different locations - expected versus unexpected location - and one where the target object is absent. 105 of those photographs were rated into three different categories depending on the difficulty. We measured the reaction times and used eye-tracking in 92 subjects (53 patients with relapse-remitting MS and with progressive multiple sclerosis and 39 healthy control subjects). Reaction times differed between the patients and healthy controls as well between the different difficulty and object location (expected, unexpected and missing). Furthermore, eye-tracking of natural viewing behaviour differentiated between MS patients and healthy subjects and was linked to cognitive impairment. Natural viewing behaviour as measured with eye-tracking can therefore be used as a predictive tool to evaluate which MS patients should undergo a detailed neuropsychological examination.
Disclosure: Johannes Gehrig was supported by travel grant from Novartis. Yavor Yalachkov was supported by travel grants from Novartis and Genzyme and received honoraria for active participation in advisory boards as well as speaking honoraria by Genzyme and Roche. Christian Förch received speaking honoraria and honoraria for active participation in advisory boards from TEVA, Roche, and Genzyme.