Contributions
Abstract: EP1537
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Executive dysfunction in multiple sclerosis (MS) has generally been partially approached, being working memory (WM) and verbal fluency more frequent analyzed. Only a few studies have focused on decision making (DM) process, mainly using tasks without explicit risk, which do not allow differentiation of DM cognitive components (impulsivity, WM, flexibility, emotion). Data are limited about relationship between DM process and regional brain volumes.
Objective: to evaluate DM process under explicit risk in multiple sclerosis patients and its relationship with prefrontal and thalamus volumes.
Methods: Cambridge Gambling Task (CGT) was used to assess DM process by a prospective and controlled study in 102 MS patients (68 female, aged 42,7± 9 and EDSS 1,86±1,3) and 55 matched healthy controls. CGT evaluates DM process under explicit risk. All patients also underwent another prefrontal task (WM, flexibility and planning) of CANTAB battery, SDMT and PASAT, in order to assess their influence in DM process by a multiple lineal regression. Finally, the relationship between MD and volumes of thalamus, lateral orbitofrontal and caudal middlefrontal (measured using Free Surfer) was analyzed using a lineal regression model.
Results: MS patients showed respect to controls a significant longer deliberation time to make a decision (p=0.037), greater impulsivity (delay aversion p =0.012), less rational choices (quality of DM p=0.002) and worse risk adjustment (p=0.040). Flexibility task explained impulsivity (R2=0.12, p=0.003) and risk taken (R2=0.07, p=0.025). Lateral-orbitofrontal and thalamus volumes predict impulsivity, quality of DM and deliberation time.
Conclusions: MS patients showed impairment in MD process under explicit risk conditions with and minor effect of flexibility in impulsivity and risk taking. Lateral-orbitofrontal and thalamus volumes seem predict DM process.
Disclosure: This research was supported by Teva.
Authors declare not having conflicts of interest respect to this work. We report all possible disclosures to be thorough. Yolanda Aladro had received speakers' honoraria from Novartis, Biogen Idec, Teva and Merck Serono; serves as a consultant and scientific advisory boards for some Pharmaceutical Industries (Teva, Novartis, Biogen Idec, Sanofi Genzyme and Merck Serono). Marta Cerezo receive support to investigate from Novartis and Teva.
Abstract: EP1537
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Executive dysfunction in multiple sclerosis (MS) has generally been partially approached, being working memory (WM) and verbal fluency more frequent analyzed. Only a few studies have focused on decision making (DM) process, mainly using tasks without explicit risk, which do not allow differentiation of DM cognitive components (impulsivity, WM, flexibility, emotion). Data are limited about relationship between DM process and regional brain volumes.
Objective: to evaluate DM process under explicit risk in multiple sclerosis patients and its relationship with prefrontal and thalamus volumes.
Methods: Cambridge Gambling Task (CGT) was used to assess DM process by a prospective and controlled study in 102 MS patients (68 female, aged 42,7± 9 and EDSS 1,86±1,3) and 55 matched healthy controls. CGT evaluates DM process under explicit risk. All patients also underwent another prefrontal task (WM, flexibility and planning) of CANTAB battery, SDMT and PASAT, in order to assess their influence in DM process by a multiple lineal regression. Finally, the relationship between MD and volumes of thalamus, lateral orbitofrontal and caudal middlefrontal (measured using Free Surfer) was analyzed using a lineal regression model.
Results: MS patients showed respect to controls a significant longer deliberation time to make a decision (p=0.037), greater impulsivity (delay aversion p =0.012), less rational choices (quality of DM p=0.002) and worse risk adjustment (p=0.040). Flexibility task explained impulsivity (R2=0.12, p=0.003) and risk taken (R2=0.07, p=0.025). Lateral-orbitofrontal and thalamus volumes predict impulsivity, quality of DM and deliberation time.
Conclusions: MS patients showed impairment in MD process under explicit risk conditions with and minor effect of flexibility in impulsivity and risk taking. Lateral-orbitofrontal and thalamus volumes seem predict DM process.
Disclosure: This research was supported by Teva.
Authors declare not having conflicts of interest respect to this work. We report all possible disclosures to be thorough. Yolanda Aladro had received speakers' honoraria from Novartis, Biogen Idec, Teva and Merck Serono; serves as a consultant and scientific advisory boards for some Pharmaceutical Industries (Teva, Novartis, Biogen Idec, Sanofi Genzyme and Merck Serono). Marta Cerezo receive support to investigate from Novartis and Teva.