Contributions
Abstract: EP1536
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment is a frequent feature in relapsing remitting multiple sclerosis (RMMS), with prevalence rates ranging from 40 to 65%. Executive functions (EF) are frequently afected in MS. Incidental learning refers to the ability of learning new information without having the intention to do it. EF are neccesary for incidental learning, however, to date, there are no studies about the relationship between them in relapsing remitting MS patients.
Objectives: To evaluate the performance on EF and incidental learning task in RMMS patients in order to get a deeper understanding of their cognitive profile.
Methods: A complete neuropsychological test battery was performed on 30 relapsing remitting MS patients and 30 healthy controls. This battery included the digit symbol substitution test (WAIS III) (incidental learning), Rey complex figure test (incidental learning) and an ecological incidental learning test. The patients group had a mean age of 40.90 years (SD=10.04), 16.70 years of formal schooling (SD=2.69), a mean premorbid estimated IQ of 103,92 (SD=6.10), 3,40 years of progression (SD=4.33) and a mean EDSS score of 1.87 (SD=2.20). Control group had a mean age of 36.77 (SD=7.53), 17.31 years of formal schooling (SD=2.70) and a mean premorbid estimated IQ of 104.94 (SD=6.42).
Results: We found significant differences in the performance on executive screening tests (p< 0,00), phonemic verbal fluency (p< 0,01), PASAT 3´´ (p< 0,00), symbol search test (p< 0,00), digit symbol substitution test (p< 0,00), processing speed index (p< 0,00), Rey complex figure test (incidental learning, p< 0,00) and in the ecological incidental learning test (p< 0,00) between groups. Positive correlations were observed on the incidental learning test, executive screening test, working memory test and processing speed index.
Conclusions: The incidental learning is impaired in RMMS patients and it is influenced by executive dysfunction. These results are important to understand these patients cognitive proflile in clinical setting, specialiy in rehabilitation context.
Disclosure: Galiani: nothing to disclose
Pagani Cassará: nothing to disclose
Sinay: nothing to disclose
Roca: nothing to disclose
Bruno: nothing to disclose
Abstract: EP1536
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Cognitive impairment is a frequent feature in relapsing remitting multiple sclerosis (RMMS), with prevalence rates ranging from 40 to 65%. Executive functions (EF) are frequently afected in MS. Incidental learning refers to the ability of learning new information without having the intention to do it. EF are neccesary for incidental learning, however, to date, there are no studies about the relationship between them in relapsing remitting MS patients.
Objectives: To evaluate the performance on EF and incidental learning task in RMMS patients in order to get a deeper understanding of their cognitive profile.
Methods: A complete neuropsychological test battery was performed on 30 relapsing remitting MS patients and 30 healthy controls. This battery included the digit symbol substitution test (WAIS III) (incidental learning), Rey complex figure test (incidental learning) and an ecological incidental learning test. The patients group had a mean age of 40.90 years (SD=10.04), 16.70 years of formal schooling (SD=2.69), a mean premorbid estimated IQ of 103,92 (SD=6.10), 3,40 years of progression (SD=4.33) and a mean EDSS score of 1.87 (SD=2.20). Control group had a mean age of 36.77 (SD=7.53), 17.31 years of formal schooling (SD=2.70) and a mean premorbid estimated IQ of 104.94 (SD=6.42).
Results: We found significant differences in the performance on executive screening tests (p< 0,00), phonemic verbal fluency (p< 0,01), PASAT 3´´ (p< 0,00), symbol search test (p< 0,00), digit symbol substitution test (p< 0,00), processing speed index (p< 0,00), Rey complex figure test (incidental learning, p< 0,00) and in the ecological incidental learning test (p< 0,00) between groups. Positive correlations were observed on the incidental learning test, executive screening test, working memory test and processing speed index.
Conclusions: The incidental learning is impaired in RMMS patients and it is influenced by executive dysfunction. These results are important to understand these patients cognitive proflile in clinical setting, specialiy in rehabilitation context.
Disclosure: Galiani: nothing to disclose
Pagani Cassará: nothing to disclose
Sinay: nothing to disclose
Roca: nothing to disclose
Bruno: nothing to disclose