Contributions
Abstract: EP1535
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Cognitive-motor interference (CMI) produced by simultaneous performance of a cognitive and motor task has been proposed as a valid marker of daily life impairment in people with Multiple Sclerosis (pwMS).
Objectives and Aim: To assess the CMI in pwMS and to explore its association with neuropsychological and other clinical variables.
Method: The dual task (DT) consisted on the performance of both cognitive (i.e. verbal fluency test) and motor (i.e. walking) tasks independently or baseline (BL), both tasks simultaneously at best capacity or double prioritization (DP), and performing only the cognitive task at best capacity while comfortably walking or cognitive prioritization (CP). Mean contrasts were conducted to compare DT performance between pwMS (N=11; remittent-recurrent course; mean EDSS= 2.364 ± 1.64) and healthy controls (HC) (N=11). Intragroup comparisons and correlations between DT parameters and neuropsychological and clinical variables were performed.
Results: Both groups were statistically similar concerning age, sex and educational level; and different in SDMT scores, 5-Digit Test, BDI-II, D-FIS, and MSQOL-54. In DT, PwMS walked significantly less distance in all conditions and, during CP provided less number of correct words than HC. There were no differences in cognitive performance between conditions in pwMS nor in HC. PwMS walked significantly less distance in DP vs BL, in CP vs BL, but there were no differences in DP vs CP; whereas HC walked less distance in CP vs BL and in CP vs DP, with no differences in DP vs BL. In pwMS, a greater number of correct words in CP was associated with better general cognitive function (SDMT), higher cognitive flexibility (5-Digit Test) and with time since the last relapse. Moreover, the distance walked in BL and DP correlated negatively with EDSS scores. The distance walked in CP correlated with a measure of fatigue (D-FIS) and self-reported quality of life (MSQOL-54), and the distance in DP correlated with those measures as well and with cognitive flexibility (5-Digit Test).
Conclusions: PwMS and HC perform differently the DT. PwMS tend not to prioritize when required, which may potentially be due to an impairment in cognitive control in situations where their limited-capacity resources would be exceeded. Moreover, CMI measures correlate with various clinical and neuropsychological variables, which also supports the idea that CMI might offer an ecologic measure of functional impairment of pwMS.
Disclosure: B. Postigo-Alonso: nothing to disclose
A. Galvao-Carmona: nothing to disclose
C. Conde-Gavilán: nothing to disclose
A. Jover: nothing to disclose
S. Molina: nothing to disclose
M.A. Peña-Toledo: nothing to disclose
R. Valverde-Moyano: nothing to disclose
E. Agüera: nothing to disclose
Abstract: EP1535
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Cognitive-motor interference (CMI) produced by simultaneous performance of a cognitive and motor task has been proposed as a valid marker of daily life impairment in people with Multiple Sclerosis (pwMS).
Objectives and Aim: To assess the CMI in pwMS and to explore its association with neuropsychological and other clinical variables.
Method: The dual task (DT) consisted on the performance of both cognitive (i.e. verbal fluency test) and motor (i.e. walking) tasks independently or baseline (BL), both tasks simultaneously at best capacity or double prioritization (DP), and performing only the cognitive task at best capacity while comfortably walking or cognitive prioritization (CP). Mean contrasts were conducted to compare DT performance between pwMS (N=11; remittent-recurrent course; mean EDSS= 2.364 ± 1.64) and healthy controls (HC) (N=11). Intragroup comparisons and correlations between DT parameters and neuropsychological and clinical variables were performed.
Results: Both groups were statistically similar concerning age, sex and educational level; and different in SDMT scores, 5-Digit Test, BDI-II, D-FIS, and MSQOL-54. In DT, PwMS walked significantly less distance in all conditions and, during CP provided less number of correct words than HC. There were no differences in cognitive performance between conditions in pwMS nor in HC. PwMS walked significantly less distance in DP vs BL, in CP vs BL, but there were no differences in DP vs CP; whereas HC walked less distance in CP vs BL and in CP vs DP, with no differences in DP vs BL. In pwMS, a greater number of correct words in CP was associated with better general cognitive function (SDMT), higher cognitive flexibility (5-Digit Test) and with time since the last relapse. Moreover, the distance walked in BL and DP correlated negatively with EDSS scores. The distance walked in CP correlated with a measure of fatigue (D-FIS) and self-reported quality of life (MSQOL-54), and the distance in DP correlated with those measures as well and with cognitive flexibility (5-Digit Test).
Conclusions: PwMS and HC perform differently the DT. PwMS tend not to prioritize when required, which may potentially be due to an impairment in cognitive control in situations where their limited-capacity resources would be exceeded. Moreover, CMI measures correlate with various clinical and neuropsychological variables, which also supports the idea that CMI might offer an ecologic measure of functional impairment of pwMS.
Disclosure: B. Postigo-Alonso: nothing to disclose
A. Galvao-Carmona: nothing to disclose
C. Conde-Gavilán: nothing to disclose
A. Jover: nothing to disclose
S. Molina: nothing to disclose
M.A. Peña-Toledo: nothing to disclose
R. Valverde-Moyano: nothing to disclose
E. Agüera: nothing to disclose