Contributions
Abstract: EP1533
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Resilience, a dynamic process of positive adaptation to notable adversity, results in psychophysical stability and higher quality of life. The increasing focus on wellness promotion in Multiple Sclerosis (MS) offers opportunity to further study the role of resilience in MS. We have previously shown the independent contribution of resilience in disability in MS. In this project we further analyzed the impact of resilience on more comprehensive assessments of cognitive and motor function.
Objective: To characterize impact of psychological resilience on measures of cognitive and physical disability in MS.
Aims: To assess a role of psychological resilience in MS.
Methods: Patients with early MS (165 RRMS, 20 CIS; < 5 years diagnosed; median EDSS = 1.0) completed the Connor-Davidson Resilience Scale 10 item (CD-RISC-10): a well-established measure of psychological resilience. Composite measures of Cognitive Efficiency (Symbol Digit Modalities Test, Stroop, Pattern Comparison, Decision Speed), Memory (Story Recall Test, Brief Visuospatial Memory Test-R, CANTAB PAL, Verbal Paired Associates), and Motor Function (Nine Hole Peg Test, Grooved Pegboard, Finger Tapping, Grip Strength) were derived. Partial correlations controlled for age, sex, education, and premorbid intelligence were used.
Results: Higher resilience was associated with better performance on composite measures of cognitive efficiency (r=.197, p=.008) and motor function (r=.293, p< .001), but not memory (r=.063, p>.10), controlling for age, sex, education, and premorbid intelligence.
Discussion: Persons with greater psychological resilience demonstrated greater cognitive efficiency and motor function. Although the underlying mechanism of this relationship requires further study, current results emphasize the importance of resilience in MS and as a potential target for intervention. Further studies are needed to understand and build psychological resilience in persons with MS.
Disclosure: S. Klineova has received compensation for advisory board work with Teva, Genentech and Biogen Idec and has given non-promotional lectures with Biogen Idec. M. T. Fabian, G. Pelle and C. Lewis have nothing to disclose. J.F. Sumowski has received compensation for consulting for Genzyme and Biogen.
Abstract: EP1533
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Resilience, a dynamic process of positive adaptation to notable adversity, results in psychophysical stability and higher quality of life. The increasing focus on wellness promotion in Multiple Sclerosis (MS) offers opportunity to further study the role of resilience in MS. We have previously shown the independent contribution of resilience in disability in MS. In this project we further analyzed the impact of resilience on more comprehensive assessments of cognitive and motor function.
Objective: To characterize impact of psychological resilience on measures of cognitive and physical disability in MS.
Aims: To assess a role of psychological resilience in MS.
Methods: Patients with early MS (165 RRMS, 20 CIS; < 5 years diagnosed; median EDSS = 1.0) completed the Connor-Davidson Resilience Scale 10 item (CD-RISC-10): a well-established measure of psychological resilience. Composite measures of Cognitive Efficiency (Symbol Digit Modalities Test, Stroop, Pattern Comparison, Decision Speed), Memory (Story Recall Test, Brief Visuospatial Memory Test-R, CANTAB PAL, Verbal Paired Associates), and Motor Function (Nine Hole Peg Test, Grooved Pegboard, Finger Tapping, Grip Strength) were derived. Partial correlations controlled for age, sex, education, and premorbid intelligence were used.
Results: Higher resilience was associated with better performance on composite measures of cognitive efficiency (r=.197, p=.008) and motor function (r=.293, p< .001), but not memory (r=.063, p>.10), controlling for age, sex, education, and premorbid intelligence.
Discussion: Persons with greater psychological resilience demonstrated greater cognitive efficiency and motor function. Although the underlying mechanism of this relationship requires further study, current results emphasize the importance of resilience in MS and as a potential target for intervention. Further studies are needed to understand and build psychological resilience in persons with MS.
Disclosure: S. Klineova has received compensation for advisory board work with Teva, Genentech and Biogen Idec and has given non-promotional lectures with Biogen Idec. M. T. Fabian, G. Pelle and C. Lewis have nothing to disclose. J.F. Sumowski has received compensation for consulting for Genzyme and Biogen.