Contributions
Abstract: EP1528
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - OCT
Introduction: Multiple Sclerosis (MS) is a chronic inflammatory disease associated with cognitive impairment. Optical Coherence Tomography (OCT), a non-invasive modality that enables the measurement of different retinal layers. Changes in the retinal nerve fiber layer (RNFL) correlate with brain atrophy. We explored the retinal Ganglion Cell-Inner Plexiform Layer (GCIPL) and RNFL changes in Relapsing-Remitting MS (RRMS) patients treated with Fingolimod or Interferon. Correlations between GCIPL and RNFL changes, and cognitive/physical disability in early RRMS were explored.
Methods: RRMS patients (with disease duration < 6 years) were recruited from the MS center between 2014 and 2017. Patients with at least one eye without clinical optic neuritis; and stable on treatment for at least 3 months were eligible to participate in the study. Clinical-demographic variables, physical disability, cognitive function, and OCT were collected at baseline (V1) and during the second year (V2). The Expanded Disability Status Score (EDSS), 25 Foot Walk Test (25-FWT), and 9-Hole Peg Test (9-HPT) were measured. Processing speed was measured using the Symbol-Digit Modality Test (SDMT).
Results: 48 patients with RRMS (25 on Interferons, 23 on Fingolimod) with mean (SD) disease duration of 38±26 months, were followed for 22.2 ± 7.7 months. No differences between treatment groups in clinical-demographic characteristics were found. Patients on Fingolimod had longer mean disease duration (45.5 ±27.8 months) than those on Interferon (30.6 ±25.4) (p=0.045). The pRNFL thickness decreased by 3.27 ± 4.3% between V1 and V2 while GCIPL decreased by 1 ± 2% (p< 0.0001). After controlling for age, gender, disease duration, educational level and depression, pRNFL at V1 correlated with SDMT (r= 0.5, p=0.001) and 9-HPT (r= -0.35, p=0.02) at V2; similarly GCIPL at V1 correlated with SDMT (r= 0.35, p=0.024) and 9-HPT (r= -0.32, p=0.034) at V2.
Conclusion: RNFL atrophy was more pronounced than GCIPL atrophy during the study period. Baseline OCT measures correlated with SDMT and 9-HPT after 2 years, supporting a role for retinal OCT as a disease progression marker in MS.
Disclosure: Nabil k. El Ayoubi: nothing to disclose
Marwa Baalbaki: nothing to disclose
Hala Darwish: nothing to disclose
Bassem Yamout: nothing to disclose
Samia J Khoury: nothing to disclose
Abstract: EP1528
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - OCT
Introduction: Multiple Sclerosis (MS) is a chronic inflammatory disease associated with cognitive impairment. Optical Coherence Tomography (OCT), a non-invasive modality that enables the measurement of different retinal layers. Changes in the retinal nerve fiber layer (RNFL) correlate with brain atrophy. We explored the retinal Ganglion Cell-Inner Plexiform Layer (GCIPL) and RNFL changes in Relapsing-Remitting MS (RRMS) patients treated with Fingolimod or Interferon. Correlations between GCIPL and RNFL changes, and cognitive/physical disability in early RRMS were explored.
Methods: RRMS patients (with disease duration < 6 years) were recruited from the MS center between 2014 and 2017. Patients with at least one eye without clinical optic neuritis; and stable on treatment for at least 3 months were eligible to participate in the study. Clinical-demographic variables, physical disability, cognitive function, and OCT were collected at baseline (V1) and during the second year (V2). The Expanded Disability Status Score (EDSS), 25 Foot Walk Test (25-FWT), and 9-Hole Peg Test (9-HPT) were measured. Processing speed was measured using the Symbol-Digit Modality Test (SDMT).
Results: 48 patients with RRMS (25 on Interferons, 23 on Fingolimod) with mean (SD) disease duration of 38±26 months, were followed for 22.2 ± 7.7 months. No differences between treatment groups in clinical-demographic characteristics were found. Patients on Fingolimod had longer mean disease duration (45.5 ±27.8 months) than those on Interferon (30.6 ±25.4) (p=0.045). The pRNFL thickness decreased by 3.27 ± 4.3% between V1 and V2 while GCIPL decreased by 1 ± 2% (p< 0.0001). After controlling for age, gender, disease duration, educational level and depression, pRNFL at V1 correlated with SDMT (r= 0.5, p=0.001) and 9-HPT (r= -0.35, p=0.02) at V2; similarly GCIPL at V1 correlated with SDMT (r= 0.35, p=0.024) and 9-HPT (r= -0.32, p=0.034) at V2.
Conclusion: RNFL atrophy was more pronounced than GCIPL atrophy during the study period. Baseline OCT measures correlated with SDMT and 9-HPT after 2 years, supporting a role for retinal OCT as a disease progression marker in MS.
Disclosure: Nabil k. El Ayoubi: nothing to disclose
Marwa Baalbaki: nothing to disclose
Hala Darwish: nothing to disclose
Bassem Yamout: nothing to disclose
Samia J Khoury: nothing to disclose