Contributions
Abstract: EP1527
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Objective: To identify correlations between specific brain regions andperformance in neuropsychological tests evaluating different cognitive functions in a large series of patients with multiple sclerosis (MS).
Methods: A total of 375 patients were evaluated with a comprehensive neuropsychological battery and with magnetic resonance imaging. Voxel-based morphometry with Statistical Parametric Mapping was conducted to analyse the correlation between cognitive performance and grey matter damage.
Results: The following correlations were found: Corsi block-tapping test with right insula; Trail Making Test with caudate nucleus, thalamus, and several cortical regions including the posterior cingulate and inferior frontal gyrus; Symbol Digit Modalities Test with caudate nucleus, thalamus, posterior cingulate, several frontal regions, insula, and cerebellum; Stroop Color and Word Test with caudate nucleus and putamen; Free and Cued Selective Reminding Test and Rey-Osterrieth Complex Figure with thalamus, precuneus, and parahippocampal gyrus; Boston Naming Test with thalamus, caudate nucleus, and hippocampus; semantic verbal fluency with thalamus and phonological verbal fluency with caudate nucleus; and Tower of Londontest with frontal lobe, caudate nucleus, and posterior cingulate.
Disclosure: Our study provides valuable data on the cortical and subcortical basis of cognitive function in MS. Neuropsychological tests mainly assessing attention and executive function showed a stronger association with caudate volume, while tests primarily evaluating memory were more strongly correlated with the thalamus. Other relevant regions were the posterior cingulate/precuneus, which were associated with attentional tasks, and several frontal regions, which were found to be correlated with planning and higher order executive functioning.
Abstract: EP1527
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Objective: To identify correlations between specific brain regions andperformance in neuropsychological tests evaluating different cognitive functions in a large series of patients with multiple sclerosis (MS).
Methods: A total of 375 patients were evaluated with a comprehensive neuropsychological battery and with magnetic resonance imaging. Voxel-based morphometry with Statistical Parametric Mapping was conducted to analyse the correlation between cognitive performance and grey matter damage.
Results: The following correlations were found: Corsi block-tapping test with right insula; Trail Making Test with caudate nucleus, thalamus, and several cortical regions including the posterior cingulate and inferior frontal gyrus; Symbol Digit Modalities Test with caudate nucleus, thalamus, posterior cingulate, several frontal regions, insula, and cerebellum; Stroop Color and Word Test with caudate nucleus and putamen; Free and Cued Selective Reminding Test and Rey-Osterrieth Complex Figure with thalamus, precuneus, and parahippocampal gyrus; Boston Naming Test with thalamus, caudate nucleus, and hippocampus; semantic verbal fluency with thalamus and phonological verbal fluency with caudate nucleus; and Tower of Londontest with frontal lobe, caudate nucleus, and posterior cingulate.
Disclosure: Our study provides valuable data on the cortical and subcortical basis of cognitive function in MS. Neuropsychological tests mainly assessing attention and executive function showed a stronger association with caudate volume, while tests primarily evaluating memory were more strongly correlated with the thalamus. Other relevant regions were the posterior cingulate/precuneus, which were associated with attentional tasks, and several frontal regions, which were found to be correlated with planning and higher order executive functioning.