Contributions
Abstract: EP1517
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Background: People with multiple sclerosis (PwMS) can exhibit perturbations in personality, including elevation in Neuroticism and diminution of Conscientiousness and Extraversion. Lower Conscientiousness and Extroversion in particular have been shown to correlate with globally decreased cortical gray matter (GM) volume in PwMS. These trait alterations influence disease trajectory and functional outcomes such as work capacity.
Objective: To identify localized patterns of cortical gray matter (GM) atrophy associated with each personality trait as measured by the NEO Five Factor Inventory (NEOFFI).
Methods: Psychological assessment and brain MRI was carried out for 131 PwMS. Surface-based cortical parcellation and measurement of cortical thickness was completed using FreeSurfer. Then, surface-based group analysis was completed to evaluate the association between localized cortical thickness and sex-corrected t-scores of Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness. In order to control for global disease progression, age and normalized whole brain volume were included as covariates in the models. Results were controlled for multiple comparisons using Monte Carlo Null-Z Simulation at a cluster-wise level of p< 0.05.
Results: Lower Conscientiousness correlated with decreased cortical thickness in two separate clusters within the left precuneus (Tmax=3.19, p< 0.001; Tmax=2.93, p=0.001), left postcentral gyrus (Tmax=3.83, p=0.001), right paracentral gyrus (Tmax=4.40, p< 0.001), and right inferior-parietal gyrus (Tmax=4.26, p< 0.001). Lower Extraversion correlated with decreased thickness in the right inferior-parietal cortex (Tmax=2.99, p=0.001). No significant correlations were observed for the remaining NEOFFI traits.
Conclusions: Findings suggest that personality trait alterations in PwMS may be driven at least in part by localized cortical GM atrophy, although longitudinal research is needed to confirm this hypothesis. These results are consistent with previous studies which indicate a correlation between cortical morphometry and personality traits Conscientiousness and Extroversion.
Disclosure: Tom Fuchs, Jose Escobar, Matthew Mallory, Jacob Silver, Cody Smith, Erin Ramgulam, Niels Bergsland, and Dejan Jakimovski have nothing to disclose.
Ralph H. B. Benedict has received research support from Accorda, Novartis, Genzyme, Biogen Idec, and Mallinkrodt, and is on the speakers' bureau for EMD Serono, and consults for Biogen Idec, Genentech, Roche, Sanofi/Genzyme, Takeda, NeuroCog Trials, and Novartis. Dr. Benedict also receives royalties for Psychological Assessment Resources: Bianca Weinstock-Guttman received honoraria as a speaker and as a consultant for Biogen Idec, Teva Pharmaceuticals, EMD Serono, Genzyme, Sanofi, Novartis and Acorda. Dr Weinstock-Guttman received research funds from Biogen Idec, Teva Pharmaceuticals, EMD Serono,Genzyme, Sanofi, Novartis, Acorda.
Robert Zivadinov received personal compensation from EMD Serono, Genzyme-Sanofi, Novartis, Celgene for speaking and consultant fees. He received financial support for research activities from Claret Medical, Genzyme-Sanofi, QuintilesIMS Health, Intekrin-Coherus, Novartis and Protembo.
Michael G. Dwyer has received consultant fees from Claret Medical and EMD Serono and research grant support from Novartis.
Abstract: EP1517
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Background: People with multiple sclerosis (PwMS) can exhibit perturbations in personality, including elevation in Neuroticism and diminution of Conscientiousness and Extraversion. Lower Conscientiousness and Extroversion in particular have been shown to correlate with globally decreased cortical gray matter (GM) volume in PwMS. These trait alterations influence disease trajectory and functional outcomes such as work capacity.
Objective: To identify localized patterns of cortical gray matter (GM) atrophy associated with each personality trait as measured by the NEO Five Factor Inventory (NEOFFI).
Methods: Psychological assessment and brain MRI was carried out for 131 PwMS. Surface-based cortical parcellation and measurement of cortical thickness was completed using FreeSurfer. Then, surface-based group analysis was completed to evaluate the association between localized cortical thickness and sex-corrected t-scores of Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness. In order to control for global disease progression, age and normalized whole brain volume were included as covariates in the models. Results were controlled for multiple comparisons using Monte Carlo Null-Z Simulation at a cluster-wise level of p< 0.05.
Results: Lower Conscientiousness correlated with decreased cortical thickness in two separate clusters within the left precuneus (Tmax=3.19, p< 0.001; Tmax=2.93, p=0.001), left postcentral gyrus (Tmax=3.83, p=0.001), right paracentral gyrus (Tmax=4.40, p< 0.001), and right inferior-parietal gyrus (Tmax=4.26, p< 0.001). Lower Extraversion correlated with decreased thickness in the right inferior-parietal cortex (Tmax=2.99, p=0.001). No significant correlations were observed for the remaining NEOFFI traits.
Conclusions: Findings suggest that personality trait alterations in PwMS may be driven at least in part by localized cortical GM atrophy, although longitudinal research is needed to confirm this hypothesis. These results are consistent with previous studies which indicate a correlation between cortical morphometry and personality traits Conscientiousness and Extroversion.
Disclosure: Tom Fuchs, Jose Escobar, Matthew Mallory, Jacob Silver, Cody Smith, Erin Ramgulam, Niels Bergsland, and Dejan Jakimovski have nothing to disclose.
Ralph H. B. Benedict has received research support from Accorda, Novartis, Genzyme, Biogen Idec, and Mallinkrodt, and is on the speakers' bureau for EMD Serono, and consults for Biogen Idec, Genentech, Roche, Sanofi/Genzyme, Takeda, NeuroCog Trials, and Novartis. Dr. Benedict also receives royalties for Psychological Assessment Resources: Bianca Weinstock-Guttman received honoraria as a speaker and as a consultant for Biogen Idec, Teva Pharmaceuticals, EMD Serono, Genzyme, Sanofi, Novartis and Acorda. Dr Weinstock-Guttman received research funds from Biogen Idec, Teva Pharmaceuticals, EMD Serono,Genzyme, Sanofi, Novartis, Acorda.
Robert Zivadinov received personal compensation from EMD Serono, Genzyme-Sanofi, Novartis, Celgene for speaking and consultant fees. He received financial support for research activities from Claret Medical, Genzyme-Sanofi, QuintilesIMS Health, Intekrin-Coherus, Novartis and Protembo.
Michael G. Dwyer has received consultant fees from Claret Medical and EMD Serono and research grant support from Novartis.