Contributions
Abstract: EP1506
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Background: Radiological characteristics of multiple sclerosis (MS) in Egypt are lacking.
Objective: This study describes the radiological characteristics of Egyptian patients with multiple sclerosis in a major tertiary referral center in Egypt.
Aim: To study the different MRI characteristics and their relation to disability progression.
Methods: This was a retrospective study including 693 Patients with MS (McDonald 2010 criteria). Their data was extracted from the database of the MS unit of Ain Shams university hospital in the period between 2015-2017. The MRI's were evaluated by an MS radiology team.
Results: A total of 693 Egyptian patients were included in this study. Females represented 72.4%. The mean age of disease onset was 26.1 ± 7.7 years. Relapsing-remitting MS (RRMS) was the most common type (76.5%). Visual and motor symptoms were the most common initial presentation. The mean Expanded Disability Status Scale (EDSS) score was 3.5 ± 2.1. Our patients showed the following MRI findings : The total T2 lesions were > 10 in 73.9%. Periventricular lesions were found in 98.7% (41.6% of them had 4-10 lesions, while 38.2% had > 10 lesions). Juxtacortical lesions were found in 84% (34.2% of them had 1-3 lesions, 31% had 4-10 lesions, and 18.8% had > 10 lesions). Infratentorial lesions were found in 69.3% (45.2% of them had 1-3 lesions and 20.8% had 4-10 lesions). Confluent lesions were found in 48.5%, T1 black holes in 52.1%, enhancing lesions in 29% and Cord lesions in 47.9%. T1 black holes, confluent lesions and infratentorial lesions showed the strongest correlation with high EDSS ( p=0.003, p< 0.001, p< 0.001 respectively).
Conclusions: Egyptian MS patients showed a radiological pattern that was similar to western countries in brain lesions but with probably more infratentorial lesions. Spinal lesions were not as frequent as Asian countries. Black holes, confluent lesions and infratentorial lesions were statistically correlated with high EDSS.
Disclosure: nothing to disclose
Abstract: EP1506
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Background: Radiological characteristics of multiple sclerosis (MS) in Egypt are lacking.
Objective: This study describes the radiological characteristics of Egyptian patients with multiple sclerosis in a major tertiary referral center in Egypt.
Aim: To study the different MRI characteristics and their relation to disability progression.
Methods: This was a retrospective study including 693 Patients with MS (McDonald 2010 criteria). Their data was extracted from the database of the MS unit of Ain Shams university hospital in the period between 2015-2017. The MRI's were evaluated by an MS radiology team.
Results: A total of 693 Egyptian patients were included in this study. Females represented 72.4%. The mean age of disease onset was 26.1 ± 7.7 years. Relapsing-remitting MS (RRMS) was the most common type (76.5%). Visual and motor symptoms were the most common initial presentation. The mean Expanded Disability Status Scale (EDSS) score was 3.5 ± 2.1. Our patients showed the following MRI findings : The total T2 lesions were > 10 in 73.9%. Periventricular lesions were found in 98.7% (41.6% of them had 4-10 lesions, while 38.2% had > 10 lesions). Juxtacortical lesions were found in 84% (34.2% of them had 1-3 lesions, 31% had 4-10 lesions, and 18.8% had > 10 lesions). Infratentorial lesions were found in 69.3% (45.2% of them had 1-3 lesions and 20.8% had 4-10 lesions). Confluent lesions were found in 48.5%, T1 black holes in 52.1%, enhancing lesions in 29% and Cord lesions in 47.9%. T1 black holes, confluent lesions and infratentorial lesions showed the strongest correlation with high EDSS ( p=0.003, p< 0.001, p< 0.001 respectively).
Conclusions: Egyptian MS patients showed a radiological pattern that was similar to western countries in brain lesions but with probably more infratentorial lesions. Spinal lesions were not as frequent as Asian countries. Black holes, confluent lesions and infratentorial lesions were statistically correlated with high EDSS.
Disclosure: nothing to disclose