Contributions
Abstract: EP1489
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: The pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) is characterized by neuro-inflammation of the central nervous system (CNS). Based on inflammatory effects of high carbohydrate intake, we investigated the role of carbohydrate to protein ratio (cho:pro ratio) in NMOSD incidence.
Method: this case-control study included 70 NMOSD patients diagnosed by international 2015 consensus criteria with disease duration< 3-years who didn't change their diet after NMOSD diagnosis and 214 healthy controls. Demographic and anthropometric data were collected. Also dietary intakes of subjects during the year prior to study in control group and the year before NMOSD diagnosis in the case group were assessed using a validated 168-item food frequency questionnaire (FFQ). Nutritionist-4 (N4) software was used to calculate cho:pro ratio.
Result: Eighty-five percent of patients in case group and 61% of controls were women. The mean age of participants was 35.34 and 43.31 years in case and control groups, respectively. The Mean carbohydrate intake increased from 363.55 to 403.86 g/d across cho:pro quintiles. Inversely, the mean protein intake decreased from 133.29 to 74.26 g/d across quintiles.
Individuals with higher cho:pro ratio met increasing risk of NMOSD. After adjustment for age, gender, Body mass index (BMI) and total energy intake the odds ratios(OR) of suffering from NMOSD were as follows: OR=3.122(95%CI: 1.04-9.30) for the second and OR=4.50(95%CI: 1.50-13.46) for the fifth quintile of cho:pro ratio compared to the first quintile (p-trend< 0.02). The other model which additionally adjusted for smoking and alcohol consumption showed OR=3.13(95%CI: 1.04-9.44) and OR=4.46(95%CI: 1.48-13.40) in the second and the fifth quintiles, respectively compared to the first quintile (p-trend< 0.02).
Conclusion: Our results suggest high dietary cho:pro ratio as a risk factor for NMOSD. Given that this study is the first investigation in this field, further researches are needed to confirm our results.
Disclosure: no potential conflict of interest for all authors
no source of funding for all authors
all authors: nothing to disclose
Abstract: EP1489
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: The pathogenesis of neuromyelitis optica spectrum disorder (NMOSD) is characterized by neuro-inflammation of the central nervous system (CNS). Based on inflammatory effects of high carbohydrate intake, we investigated the role of carbohydrate to protein ratio (cho:pro ratio) in NMOSD incidence.
Method: this case-control study included 70 NMOSD patients diagnosed by international 2015 consensus criteria with disease duration< 3-years who didn't change their diet after NMOSD diagnosis and 214 healthy controls. Demographic and anthropometric data were collected. Also dietary intakes of subjects during the year prior to study in control group and the year before NMOSD diagnosis in the case group were assessed using a validated 168-item food frequency questionnaire (FFQ). Nutritionist-4 (N4) software was used to calculate cho:pro ratio.
Result: Eighty-five percent of patients in case group and 61% of controls were women. The mean age of participants was 35.34 and 43.31 years in case and control groups, respectively. The Mean carbohydrate intake increased from 363.55 to 403.86 g/d across cho:pro quintiles. Inversely, the mean protein intake decreased from 133.29 to 74.26 g/d across quintiles.
Individuals with higher cho:pro ratio met increasing risk of NMOSD. After adjustment for age, gender, Body mass index (BMI) and total energy intake the odds ratios(OR) of suffering from NMOSD were as follows: OR=3.122(95%CI: 1.04-9.30) for the second and OR=4.50(95%CI: 1.50-13.46) for the fifth quintile of cho:pro ratio compared to the first quintile (p-trend< 0.02). The other model which additionally adjusted for smoking and alcohol consumption showed OR=3.13(95%CI: 1.04-9.44) and OR=4.46(95%CI: 1.48-13.40) in the second and the fifth quintiles, respectively compared to the first quintile (p-trend< 0.02).
Conclusion: Our results suggest high dietary cho:pro ratio as a risk factor for NMOSD. Given that this study is the first investigation in this field, further researches are needed to confirm our results.
Disclosure: no potential conflict of interest for all authors
no source of funding for all authors
all authors: nothing to disclose