Contributions
Abstract: EP1487
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: Vitamin D and obesity may be related to the pathogenesis and disease activity of multiple sclerosis (MS).
Objectives: To study the role of vitamin D and obesity in the pathogenesis and disease activity of MS in Egypt.
Aims: To assess the correlation between the serum level of vitamin D, body mass index (BMI) and the Expanded Disability Status Scale (EDSS) in a sample of Egyptian MS patients.
Methods: This was a retrospective study that included 130 MS patients who were recruited consecutively among the patients attending the MS unit of Ain Shams University Hospital, Cairo, in the period between December 2017 - March 2018. The serum level of 25(OH) D, BMI and EDSS were recorded.
Results: Females represented 77.7% of the study sample. The mean age was 32.4±8.2 years. MS types were: RRMS 83.1%, SPMS 14.6% and PPMS in 2.3%. Serum level of vitamin D was deficient (less than 10ng/ml) in 69.2% and insufficient (10-30ng/ml) in 19.2% of the study population. The mean BMI was 25.5±4.7 kg/sqm (classified as obese). The mean EDSS was 3.5±1.9. The relationship between the EDSS score and vitamin D level was inversely correlated; all patients with EDSS ≤ 2 had sufficient levels while all patients with EDSS ≥ 4.5 had deficient levels. High EDSS scores were statistically correlated (p< 0.001) to high BMI and low Log vitamin D levels. An inverse correlation was found between the BMI and log vitamin D. Conclusions: Vitamin D deficiency and obesity are predominant among Egyptian MS patients and may possibly play a role in the pathogenesis and progression of MS in Egypt. Higher EDSS scores were statistically significantly correlated to lower vitamin D levels and higher BMI.
Disclosure: nothing to disclose
Abstract: EP1487
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: Vitamin D and obesity may be related to the pathogenesis and disease activity of multiple sclerosis (MS).
Objectives: To study the role of vitamin D and obesity in the pathogenesis and disease activity of MS in Egypt.
Aims: To assess the correlation between the serum level of vitamin D, body mass index (BMI) and the Expanded Disability Status Scale (EDSS) in a sample of Egyptian MS patients.
Methods: This was a retrospective study that included 130 MS patients who were recruited consecutively among the patients attending the MS unit of Ain Shams University Hospital, Cairo, in the period between December 2017 - March 2018. The serum level of 25(OH) D, BMI and EDSS were recorded.
Results: Females represented 77.7% of the study sample. The mean age was 32.4±8.2 years. MS types were: RRMS 83.1%, SPMS 14.6% and PPMS in 2.3%. Serum level of vitamin D was deficient (less than 10ng/ml) in 69.2% and insufficient (10-30ng/ml) in 19.2% of the study population. The mean BMI was 25.5±4.7 kg/sqm (classified as obese). The mean EDSS was 3.5±1.9. The relationship between the EDSS score and vitamin D level was inversely correlated; all patients with EDSS ≤ 2 had sufficient levels while all patients with EDSS ≥ 4.5 had deficient levels. High EDSS scores were statistically correlated (p< 0.001) to high BMI and low Log vitamin D levels. An inverse correlation was found between the BMI and log vitamin D. Conclusions: Vitamin D deficiency and obesity are predominant among Egyptian MS patients and may possibly play a role in the pathogenesis and progression of MS in Egypt. Higher EDSS scores were statistically significantly correlated to lower vitamin D levels and higher BMI.
Disclosure: nothing to disclose