Contributions
Abstract: EP1486
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: Neuromyelitis optica spectrum disorder (NMOSD) is referred to inflammatory demyelinating disease of the central nervous system. Data suggest that the presence of a highly specific serum autoantibody (NMO-IgG) that reacts against the water channel aquaporin-4 (AQP4), causes the inflammation and demyelination in NMOSD .Here, we studied the association between NMO-IgG and as cigarette smoking and alcohol use.
Methods: A case-control study was conducted in a referral hospital center in Tehran from 2015 to 2016 among patients with a definite diagnosis of NMOSD based on the international 2015 consensus criteria to assess the possible relation between positivity of NMO-IgG and environmental factors such as cigarette smoking and alcohol use. The enzyme-linked immunosorbent assay (ELISA) was used for checking the presence of aquaporin-4 immunoglobulin G (AQP4-IgG) status. Most of the tests have been completedduring the relapse before receiving corticosteroid. We designed a questionnaire to cover important epidemiological data of NMOSD and conducted structured face to face interviews patients by trained interviewers to collect the data.Finally the logistic regression was appliedin analysis via SPSS software package.
Results: The presence of NMO-IgG was positive for 71 (54.2%) and negative for 60 (45.8%) of patients.
The increased NMO-IgG positivity odds among life time smokers (OR = 3.24; 95% CI= 1.16, 9.08), Current smokers (OR = 6.08; 95% CI= 1.26, 29.39), passive smokers (OR = 2.22; 95% CI= 1.10, 4.50),and Whisky/vodka consumption (OR = 3.65; 95 CI= 1.21, 10.93) was observed.
An association between water-pipe smoking, bear and wine intake and NMO-IgG positivity was not observed (P value > 0.05).
Conclusion: life time and current smoking, passive smoking and Whisky/vodka consumption are risk factors for NMO-IgG positivity. Studies have been revealed the role of smoking in development of autoantibodies.
Therefore NMO-IgG as an important autoantibodies is not an exception.
Disclosure: Conflict of interest: None for all authors
Nothing to disclose: for all authors
Source of funding: Tehran University of Medical Sciences
Abstract: EP1486
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: Neuromyelitis optica spectrum disorder (NMOSD) is referred to inflammatory demyelinating disease of the central nervous system. Data suggest that the presence of a highly specific serum autoantibody (NMO-IgG) that reacts against the water channel aquaporin-4 (AQP4), causes the inflammation and demyelination in NMOSD .Here, we studied the association between NMO-IgG and as cigarette smoking and alcohol use.
Methods: A case-control study was conducted in a referral hospital center in Tehran from 2015 to 2016 among patients with a definite diagnosis of NMOSD based on the international 2015 consensus criteria to assess the possible relation between positivity of NMO-IgG and environmental factors such as cigarette smoking and alcohol use. The enzyme-linked immunosorbent assay (ELISA) was used for checking the presence of aquaporin-4 immunoglobulin G (AQP4-IgG) status. Most of the tests have been completedduring the relapse before receiving corticosteroid. We designed a questionnaire to cover important epidemiological data of NMOSD and conducted structured face to face interviews patients by trained interviewers to collect the data.Finally the logistic regression was appliedin analysis via SPSS software package.
Results: The presence of NMO-IgG was positive for 71 (54.2%) and negative for 60 (45.8%) of patients.
The increased NMO-IgG positivity odds among life time smokers (OR = 3.24; 95% CI= 1.16, 9.08), Current smokers (OR = 6.08; 95% CI= 1.26, 29.39), passive smokers (OR = 2.22; 95% CI= 1.10, 4.50),and Whisky/vodka consumption (OR = 3.65; 95 CI= 1.21, 10.93) was observed.
An association between water-pipe smoking, bear and wine intake and NMO-IgG positivity was not observed (P value > 0.05).
Conclusion: life time and current smoking, passive smoking and Whisky/vodka consumption are risk factors for NMO-IgG positivity. Studies have been revealed the role of smoking in development of autoantibodies.
Therefore NMO-IgG as an important autoantibodies is not an exception.
Disclosure: Conflict of interest: None for all authors
Nothing to disclose: for all authors
Source of funding: Tehran University of Medical Sciences