Contributions
Abstract: EP1485
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon autoimmune disorder. Until now dietary risk factors of NMOSD remained unknown. The present study aimed to determine the effects of protein consumption on NMOSD risk.
Method: we performed a case-control study in sina hospital which has the only NMOSD specialist clinic in Tehran, Iran. We enrolled 70 cases with definite diagnosis based on NMOSD international consensus criteria published in 2015 and 214 controls. Cases were included in the study if they didn't change their diet after NMOSD onset and had disease duration less than 3 years. Demographic and anthropometric information were collected. Data on nutritional intake during the past year of study obtained by a validated 168-items food frequency questionnaire (FFQ) in control group. For completing the same FFQ, cases were asked to report dietary consumption of the year prior of NMOSD diagnosis. Dietary analysis was performed using nutritionist 4 (N4) software.
Result: The mean age of individuals were 35.34 years among cases and 43.31 years in control group. Eighty-five percent of patients in case group and 61% of control groups were women. After adjustment for age, gender, body mass index (BMI), total energy intake, smoking and alcohol consumption, total protein intake has been associated with 61% decrease in NMOSD risk (OR=0.39;95%CI: 0.18-0.83; p-for-trend:0.01) in third tertile, compared with first tertile. Also higher poultry intake in third tertile diminished NMOSD risk by 64% (OR=0.36; 95%CI: 0.16-0.83; p-for-trend:0.01:0.01). Conversely, a higher consumption of red and processed-meat was positively associated with a 2.31 folds increase risk of NMOSD (95%CI:1.10-4.84; p-for-trend:0.01) in third tertile of red and processed-meat intake.
Conclusion: Our finding proposed probable protective effects of a diet containing high protein with white meat source against NMOSD. Conversely, high red and processed- meat consumption might be a risk factor for NMOSD.
Disclosure: no conflict of interest and source of funding for all authors
all authors: nothing to disclose
Abstract: EP1485
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Environmental factors
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon autoimmune disorder. Until now dietary risk factors of NMOSD remained unknown. The present study aimed to determine the effects of protein consumption on NMOSD risk.
Method: we performed a case-control study in sina hospital which has the only NMOSD specialist clinic in Tehran, Iran. We enrolled 70 cases with definite diagnosis based on NMOSD international consensus criteria published in 2015 and 214 controls. Cases were included in the study if they didn't change their diet after NMOSD onset and had disease duration less than 3 years. Demographic and anthropometric information were collected. Data on nutritional intake during the past year of study obtained by a validated 168-items food frequency questionnaire (FFQ) in control group. For completing the same FFQ, cases were asked to report dietary consumption of the year prior of NMOSD diagnosis. Dietary analysis was performed using nutritionist 4 (N4) software.
Result: The mean age of individuals were 35.34 years among cases and 43.31 years in control group. Eighty-five percent of patients in case group and 61% of control groups were women. After adjustment for age, gender, body mass index (BMI), total energy intake, smoking and alcohol consumption, total protein intake has been associated with 61% decrease in NMOSD risk (OR=0.39;95%CI: 0.18-0.83; p-for-trend:0.01) in third tertile, compared with first tertile. Also higher poultry intake in third tertile diminished NMOSD risk by 64% (OR=0.36; 95%CI: 0.16-0.83; p-for-trend:0.01:0.01). Conversely, a higher consumption of red and processed-meat was positively associated with a 2.31 folds increase risk of NMOSD (95%CI:1.10-4.84; p-for-trend:0.01) in third tertile of red and processed-meat intake.
Conclusion: Our finding proposed probable protective effects of a diet containing high protein with white meat source against NMOSD. Conversely, high red and processed- meat consumption might be a risk factor for NMOSD.
Disclosure: no conflict of interest and source of funding for all authors
all authors: nothing to disclose