Contributions
Abstract: EP1472
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Genetics/Epigenetics
Background: Multiple sclerosis (MS) is a disease in which family distribution, genetic/environmental factors, and geographical location has been well documented worldwide to have effect on prevalence and incidence. With the increased incidence of MS in Puerto Rico (PR), family distribution correlation is a factor that requires further investigation in order to describe the risk it represents in the Puerto Rican population. From 2013 to 2016, a total of 583 new cases of MS were diagnosed in PR. The genetic makeup of the Puerto Rican population is comprised of African American, Native American, and European ancestry. It is well-documented that descendants of European ancestry have increased likelihood of developing MS. Research on familial aggregation seems to be a good source to address the relationship between genetic susceptibility and environmental factors that trigger the onset of MS in a specific population.
Objective: Analyze the presence of MS patients who have family member with MS in hopes of further elucidating the possible genetic factors associated with MS
Methods: As part of this study, we investigate a population of patients with MS who attend to San Juan MS Center to identify if they have a first, second or third-degree relative that is also affected with MS. This effort was performed in an attempt to describe the risk of developing MS within a family with relatives with previous history of the condition and to describe the prevalence of MS between relatives in Puerto Rico. For this, 405 patients were analyzed using descriptive statistics.
Results: 10.1% of MS patients had one or more family members with MS. The most common family member with MS among the studied population was male cousins from mother's side (16.1%). This was followed by fathers and sisters (both 12.5%), and female cousins on mother's side (10.7%).
Conclusion: Here we show that 10.1% of MS patients have a family member with MS and that the most common family relation was male cousins from mother's side. As previously stated, Puerto Ricans have a European, African, and Native American genetic composition. However, it has been shown that most of the PR population has higher percentages of European ancestry. This together with the family data presented here suggest that further genetic analysis should be performed on this population in order to establish a possible genetic marker for MS in this Hispanic population.
Disclosure: Nothing to disclose
Abstract: EP1472
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Genetics/Epigenetics
Background: Multiple sclerosis (MS) is a disease in which family distribution, genetic/environmental factors, and geographical location has been well documented worldwide to have effect on prevalence and incidence. With the increased incidence of MS in Puerto Rico (PR), family distribution correlation is a factor that requires further investigation in order to describe the risk it represents in the Puerto Rican population. From 2013 to 2016, a total of 583 new cases of MS were diagnosed in PR. The genetic makeup of the Puerto Rican population is comprised of African American, Native American, and European ancestry. It is well-documented that descendants of European ancestry have increased likelihood of developing MS. Research on familial aggregation seems to be a good source to address the relationship between genetic susceptibility and environmental factors that trigger the onset of MS in a specific population.
Objective: Analyze the presence of MS patients who have family member with MS in hopes of further elucidating the possible genetic factors associated with MS
Methods: As part of this study, we investigate a population of patients with MS who attend to San Juan MS Center to identify if they have a first, second or third-degree relative that is also affected with MS. This effort was performed in an attempt to describe the risk of developing MS within a family with relatives with previous history of the condition and to describe the prevalence of MS between relatives in Puerto Rico. For this, 405 patients were analyzed using descriptive statistics.
Results: 10.1% of MS patients had one or more family members with MS. The most common family member with MS among the studied population was male cousins from mother's side (16.1%). This was followed by fathers and sisters (both 12.5%), and female cousins on mother's side (10.7%).
Conclusion: Here we show that 10.1% of MS patients have a family member with MS and that the most common family relation was male cousins from mother's side. As previously stated, Puerto Ricans have a European, African, and Native American genetic composition. However, it has been shown that most of the PR population has higher percentages of European ancestry. This together with the family data presented here suggest that further genetic analysis should be performed on this population in order to establish a possible genetic marker for MS in this Hispanic population.
Disclosure: Nothing to disclose