Contributions
Abstract: EP1442
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Objective: Behcet´s disease (BD) could occasionally present a differential diagnosis challenge in patients with optic neuropathy, which has rarely been reported in BD. Multicenter study presented here was aimed to show clinical profile, features and neuro-imaging findings of BD patients with ON.
Methods: Data from five different university hospitals were reviewed retrospectively, and patients with BD and ON were evaluated. Patients with secondary optic nerve damage were excluded. The cohort was divided into 2 groups and their findings were compared; (1) those already diagnosed with BD when ON developed (BD>ON group) and (2) those diagnosed with BD in further evaluation ON (ON>BD group).
Results: There were 25 BD patients with ON (13 males). Among these, 13 had ON>BD (6 males), and 12 had BD>ON (7 males). 17 patients had unilateral ON, and 7 patients had recurrent ON. BD>ON patients were significantly older. Disc edema was seen more in ON>BD patients (10 vs 3). 14 patients also had uveitis. There was other neurological involvement in 8 patients; in BD>ON group all 4 had MS-like neurological presentation. However, in ON>BD group, 3 had typical parenchymal involvement, and one had MS-like neurological presentation. All patients except one received immunsuppressive medications or corticosteroids or both. Prognosis was favourable in most: vision improved in 20 patients, more often in those receiving combined therapies.
Conclusion: BD may be diagnosed earlier if it is considered and investigated during the assessment of ON. Prognosis of ON related with BD seem to be favourable. Immunsuppressants should be given along with corticosteroids. MS-like presentations should also be kept in mind in patients with BD and ON. Further larger multi-center studies are needed to confirm these observations.
Disclosure: Gulden Akdal, nothing to disclose
Hulya Ertasoglu Toydemir, nothing to disclose
Osman Saatci, nothing to disclose
Ugur Uygunoglu, nothing to disclose
Burcu Altunrende, nothing to disclose
Sabahattin Saip, nothing to disclose
Aylin Yaman, nothing to disclose
Pembe Keskinoglu, nothing to disclose
Suzan Guven Yılmaz, nothing to disclose
Meltem Soylev Bajin, nothing to disclose
Nese Celebisoy, nothing to disclose
Aksel Siva, nothing to disclose
Gulsen Akman-Demir, nothing to disclose
Abstract: EP1442
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Objective: Behcet´s disease (BD) could occasionally present a differential diagnosis challenge in patients with optic neuropathy, which has rarely been reported in BD. Multicenter study presented here was aimed to show clinical profile, features and neuro-imaging findings of BD patients with ON.
Methods: Data from five different university hospitals were reviewed retrospectively, and patients with BD and ON were evaluated. Patients with secondary optic nerve damage were excluded. The cohort was divided into 2 groups and their findings were compared; (1) those already diagnosed with BD when ON developed (BD>ON group) and (2) those diagnosed with BD in further evaluation ON (ON>BD group).
Results: There were 25 BD patients with ON (13 males). Among these, 13 had ON>BD (6 males), and 12 had BD>ON (7 males). 17 patients had unilateral ON, and 7 patients had recurrent ON. BD>ON patients were significantly older. Disc edema was seen more in ON>BD patients (10 vs 3). 14 patients also had uveitis. There was other neurological involvement in 8 patients; in BD>ON group all 4 had MS-like neurological presentation. However, in ON>BD group, 3 had typical parenchymal involvement, and one had MS-like neurological presentation. All patients except one received immunsuppressive medications or corticosteroids or both. Prognosis was favourable in most: vision improved in 20 patients, more often in those receiving combined therapies.
Conclusion: BD may be diagnosed earlier if it is considered and investigated during the assessment of ON. Prognosis of ON related with BD seem to be favourable. Immunsuppressants should be given along with corticosteroids. MS-like presentations should also be kept in mind in patients with BD and ON. Further larger multi-center studies are needed to confirm these observations.
Disclosure: Gulden Akdal, nothing to disclose
Hulya Ertasoglu Toydemir, nothing to disclose
Osman Saatci, nothing to disclose
Ugur Uygunoglu, nothing to disclose
Burcu Altunrende, nothing to disclose
Sabahattin Saip, nothing to disclose
Aylin Yaman, nothing to disclose
Pembe Keskinoglu, nothing to disclose
Suzan Guven Yılmaz, nothing to disclose
Meltem Soylev Bajin, nothing to disclose
Nese Celebisoy, nothing to disclose
Aksel Siva, nothing to disclose
Gulsen Akman-Demir, nothing to disclose