Contributions
Abstract: EP1418
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: There are no validated, self-administered scale that assess dimensions for upper limb functions. Proximal and distal strength may be rated using a dynamometer, although normative data are not available.
Objectives: Developing: a set of normative data for both objective and subjective measures of upper limb function and a self-administered MS-specific scale.
Methods:
Phase 1
A literature review confirmed that there is no specific measure. The panel identified 4 scales used in other neurological conditions: Manual Ability Measure (MAM-36), Disabilities of The Arm, Shoulder and Hand (DASH), Motor Activity Long (MAL)
Phase 2
Translation and adaptation of scales (MAM-36, DASH, MAL):
- the questionnaire has been fulfilled by 5 MS patients followed by second expert meeting
- the final version has been tested in the final sample
183 patients enrolled: 125 F/58 M; mean age: 47,18 years; mean EDSS: 4.05. They were evaluated using: hand-grip; 9Hole Peg Test (9HPT); Box and Block (BB); MAM-36; DASH.
Results:
Correlation between upper-extremity function tests (* p< .05 ** p< .01) BB left vs right: 0.88**; 9HPT(Right) vs BB(right): -.47**; 9HPT(Right) vs BB(left): -.38**; 9HPT(left) vs BB(right): -.35**; 9HPT(left) vs BB(left): -.41**; 9HPT(left) vs BB(right): .63**; HAND-GRIP (Right) vs BB(Right): .09; HAND-GRIP (Right) vs BB(left) -.01; HAND-GRIP (Right) vs 9 HPT(Right): -.06; HAND-GRIP (Right) vs 9 HPT(Left): 0.01; HAND-GRIP (Left) vs BB(Right): 0.01; HAND-GRIP (Left) vs BB(Left): .03; 9 HPT(Right) vs HAND-GRIP (Left): .04; HAND-GRIP (Left) vs 9 HPT(Left): -.06; HAND-GRIP (Left) vs HAND-GRIP (Right): .85**.
Discussion and conclusion: In conclusion, we found:
- A strong inter-correlation between right and left hand scores for BB, 9HPT and hand-grip
- A moderate negative correlation between BB and 9HPT (both hands), but not a correlation with hand-grip score.
- A strong negative correlation between MAM-36 and DASH and a moderate correlation of both with BB and 9HPT
Disclosure: Dr. Solaro, Dr.Patti and Dr. Prosperini served on advisory boards of the following companies: Biogen Idec, Merck Serono. He received speaking honoraria from Bayer Schering, Biogen Idec, Merck Serono, Almirall, Teva, Genzyme. He received research grants and support from the Italian MS Society Research Foundation (Fondazione Italiana Sclerosi Multipla).
Abstract: EP1418
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: There are no validated, self-administered scale that assess dimensions for upper limb functions. Proximal and distal strength may be rated using a dynamometer, although normative data are not available.
Objectives: Developing: a set of normative data for both objective and subjective measures of upper limb function and a self-administered MS-specific scale.
Methods:
Phase 1
A literature review confirmed that there is no specific measure. The panel identified 4 scales used in other neurological conditions: Manual Ability Measure (MAM-36), Disabilities of The Arm, Shoulder and Hand (DASH), Motor Activity Long (MAL)
Phase 2
Translation and adaptation of scales (MAM-36, DASH, MAL):
- the questionnaire has been fulfilled by 5 MS patients followed by second expert meeting
- the final version has been tested in the final sample
183 patients enrolled: 125 F/58 M; mean age: 47,18 years; mean EDSS: 4.05. They were evaluated using: hand-grip; 9Hole Peg Test (9HPT); Box and Block (BB); MAM-36; DASH.
Results:
Correlation between upper-extremity function tests (* p< .05 ** p< .01) BB left vs right: 0.88**; 9HPT(Right) vs BB(right): -.47**; 9HPT(Right) vs BB(left): -.38**; 9HPT(left) vs BB(right): -.35**; 9HPT(left) vs BB(left): -.41**; 9HPT(left) vs BB(right): .63**; HAND-GRIP (Right) vs BB(Right): .09; HAND-GRIP (Right) vs BB(left) -.01; HAND-GRIP (Right) vs 9 HPT(Right): -.06; HAND-GRIP (Right) vs 9 HPT(Left): 0.01; HAND-GRIP (Left) vs BB(Right): 0.01; HAND-GRIP (Left) vs BB(Left): .03; 9 HPT(Right) vs HAND-GRIP (Left): .04; HAND-GRIP (Left) vs 9 HPT(Left): -.06; HAND-GRIP (Left) vs HAND-GRIP (Right): .85**.
Discussion and conclusion: In conclusion, we found:
- A strong inter-correlation between right and left hand scores for BB, 9HPT and hand-grip
- A moderate negative correlation between BB and 9HPT (both hands), but not a correlation with hand-grip score.
- A strong negative correlation between MAM-36 and DASH and a moderate correlation of both with BB and 9HPT
Disclosure: Dr. Solaro, Dr.Patti and Dr. Prosperini served on advisory boards of the following companies: Biogen Idec, Merck Serono. He received speaking honoraria from Bayer Schering, Biogen Idec, Merck Serono, Almirall, Teva, Genzyme. He received research grants and support from the Italian MS Society Research Foundation (Fondazione Italiana Sclerosi Multipla).