Contributions
Abstract: EP1414
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: The Composite Autonomic Scoring Scale (CASS) has been validated for assessment of dysautonomia in people with clinically isolated syndrome (pwCIS). The aim of this study was to investigate the evolution of dysautonomia in pwCIS over two-year follow-up.
Methods: 121 pwCIS (85 females, mean age 32.15±8.74, median EDSS 1 (0 - 3.5)) performed CASS at baseline and 84 after two-year follow-up. The CASS is s further divided into three indices - adrenergic, cardiovagal and sudomotor. Adrenergic index (AI) is calculated from blood pressure responses to the Valsalva maneuver and tilt table test, cardiovagal index (CI) from respiratory sinus arrhythmia (RSA) and Valsavla ratio (VR), and sudomotor index (SI) using quantitative sudomotor axon reflex test (QSART).
Results: Baseline median CASS was 1 (0-6) (AI 0 (0-3), CI 0 (0-2) and SI 0 (0-3)). At M24, median CASS was 1 (0-5) (AI 0 (0-3), CI 0 (0-1) and SI 0 (0-3)). There was no difference in CASS, AI and CI at baseline and after two years (p=0.119, p=0.335 and p=1.000, respectively). However, RSA was significantly lower after two years (23.6±8.1 vs 21.7±8.0, p=0.01), while there was no difference in VR (p=0.467). Significantly more patients developed pathological QSART response after two years on the forearm, distal lower leg and foot (p=0.001, p=0.002 and p=0.001, respectively).
Conclusion: While there is no significant change in sympathetic adrenergic and parasympathetic function in pwCIS, substantial proportion of pwCIS experience worsening of sudomotor function over 24 months of follow-up.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622.
Abstract: EP1414
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: The Composite Autonomic Scoring Scale (CASS) has been validated for assessment of dysautonomia in people with clinically isolated syndrome (pwCIS). The aim of this study was to investigate the evolution of dysautonomia in pwCIS over two-year follow-up.
Methods: 121 pwCIS (85 females, mean age 32.15±8.74, median EDSS 1 (0 - 3.5)) performed CASS at baseline and 84 after two-year follow-up. The CASS is s further divided into three indices - adrenergic, cardiovagal and sudomotor. Adrenergic index (AI) is calculated from blood pressure responses to the Valsalva maneuver and tilt table test, cardiovagal index (CI) from respiratory sinus arrhythmia (RSA) and Valsavla ratio (VR), and sudomotor index (SI) using quantitative sudomotor axon reflex test (QSART).
Results: Baseline median CASS was 1 (0-6) (AI 0 (0-3), CI 0 (0-2) and SI 0 (0-3)). At M24, median CASS was 1 (0-5) (AI 0 (0-3), CI 0 (0-1) and SI 0 (0-3)). There was no difference in CASS, AI and CI at baseline and after two years (p=0.119, p=0.335 and p=1.000, respectively). However, RSA was significantly lower after two years (23.6±8.1 vs 21.7±8.0, p=0.01), while there was no difference in VR (p=0.467). Significantly more patients developed pathological QSART response after two years on the forearm, distal lower leg and foot (p=0.001, p=0.002 and p=0.001, respectively).
Conclusion: While there is no significant change in sympathetic adrenergic and parasympathetic function in pwCIS, substantial proportion of pwCIS experience worsening of sudomotor function over 24 months of follow-up.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622.