Contributions
Abstract: EP1397
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: Although CI is common in MS patients it is difficult to detect in clinical practice, and high sensitivity and specificity cognitive tests for diagnosis such as the Brief Repeatable Battery of Neuropsychological test (BRB-N), require the intervention of neuropsychologists or trained personnel. The MS-COG-e consisted of electronically-matched 10 pairs of pictograms and was developed as an easy-to-administer CI screening tool. The MS-COG-e assesses memory, speed of information processing, attention and frontal executive functions.
Objective: To validate an electronic and brief screening scale (MS-COG-e) for CI among MS patients.
Methods: Cross-sectional, observational study that included adult patients, diagnosed with MS (McDonald 2010), Expanded Disability Status Scale (EDSS) score ≤ 6.5, no relapses/corticosteroid treatment within last 2 months and no depression symptoms (according to the Beck Depression Inventory[BDI-II]). Patients completed on the same day (among others) the BRB-N (“gold-standard” for MS patients) and MS-COG-e (higher scores more CI): pictogram-score (0-10 matchings) and pictogram-time (0-600 seconds). The MS-COG-e feasibility, reliability test-retest (coefficient of intraclass correlation [IC]) and predictivity (receiver operating characteristic [ROC] curve) were assessed.
Results: 194 patients (59% female) were included from 3 Spanish centres: mean (standard deviation) age of 42(9) years, mean MS evolution of 10(7) years, 90% had relapsing-remitting MS, 86% had disease-modifying treatment and median (interquartile range) EDSS of 2.0 (1.0-3.5). According to BRB-N, 27% of patients had CI. All patients did the pictogram with pictogram-time ceiling effects only in CI patients. The IC and ROC curve were 0.09 and 0.57 for pictogram-score, and 0.48 and 0.71 for pictogram-time. At cut-off point ≥ 60 seconds reaches a sensitivity=0.75 and a specificity=0.51.
Conclusions: The MS-COG-e showed good psychometric properties and time to complete the pictogram had an acceptable diagnostic accuracy in patients with low disability (median EDSS=2). This easy and quick tool can help neurologists to identify CI in MS patients that should be further assessed by neuropsychologists to confirm CI diagnosis.
Disclosure: This study has been done through a funding from UCAM, Universidad Católica San Antonio de Murcia.
JEML: Nothing to disclose in the elaboration of this study.
JMPG: Nothing to disclose in the elaboration of this study.
JJV: Nothing to disclose in the elaboration of this study.
IJM: Nothing to disclose in the elaboration of this study.
RCD: Nothing to disclose in the elaboration of this study.
ECG: Nothing to disclose in the elaboration of this study.
RHC: Nothing to disclose in the elaboration of this study.
EGM: Nothing to disclose in the elaboration of this study.
MCS: Nothing to disclose in the elaboration of this study.
ECA: Nothing to disclose in the elaboration of this study.
IC: Nothing to disclose in the elaboration of this study.
ASB: Nothing to disclose in the elaboration of this study.
TCT: Nothing to disclose in the elaboration of this study.
JMCM: Nothing to disclose in the elaboration of this study.
LFR: Nothing to disclose in the elaboration of this study.
JOU: Nothing to disclose in the elaboration of this study.
Abstract: EP1397
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: Although CI is common in MS patients it is difficult to detect in clinical practice, and high sensitivity and specificity cognitive tests for diagnosis such as the Brief Repeatable Battery of Neuropsychological test (BRB-N), require the intervention of neuropsychologists or trained personnel. The MS-COG-e consisted of electronically-matched 10 pairs of pictograms and was developed as an easy-to-administer CI screening tool. The MS-COG-e assesses memory, speed of information processing, attention and frontal executive functions.
Objective: To validate an electronic and brief screening scale (MS-COG-e) for CI among MS patients.
Methods: Cross-sectional, observational study that included adult patients, diagnosed with MS (McDonald 2010), Expanded Disability Status Scale (EDSS) score ≤ 6.5, no relapses/corticosteroid treatment within last 2 months and no depression symptoms (according to the Beck Depression Inventory[BDI-II]). Patients completed on the same day (among others) the BRB-N (“gold-standard” for MS patients) and MS-COG-e (higher scores more CI): pictogram-score (0-10 matchings) and pictogram-time (0-600 seconds). The MS-COG-e feasibility, reliability test-retest (coefficient of intraclass correlation [IC]) and predictivity (receiver operating characteristic [ROC] curve) were assessed.
Results: 194 patients (59% female) were included from 3 Spanish centres: mean (standard deviation) age of 42(9) years, mean MS evolution of 10(7) years, 90% had relapsing-remitting MS, 86% had disease-modifying treatment and median (interquartile range) EDSS of 2.0 (1.0-3.5). According to BRB-N, 27% of patients had CI. All patients did the pictogram with pictogram-time ceiling effects only in CI patients. The IC and ROC curve were 0.09 and 0.57 for pictogram-score, and 0.48 and 0.71 for pictogram-time. At cut-off point ≥ 60 seconds reaches a sensitivity=0.75 and a specificity=0.51.
Conclusions: The MS-COG-e showed good psychometric properties and time to complete the pictogram had an acceptable diagnostic accuracy in patients with low disability (median EDSS=2). This easy and quick tool can help neurologists to identify CI in MS patients that should be further assessed by neuropsychologists to confirm CI diagnosis.
Disclosure: This study has been done through a funding from UCAM, Universidad Católica San Antonio de Murcia.
JEML: Nothing to disclose in the elaboration of this study.
JMPG: Nothing to disclose in the elaboration of this study.
JJV: Nothing to disclose in the elaboration of this study.
IJM: Nothing to disclose in the elaboration of this study.
RCD: Nothing to disclose in the elaboration of this study.
ECG: Nothing to disclose in the elaboration of this study.
RHC: Nothing to disclose in the elaboration of this study.
EGM: Nothing to disclose in the elaboration of this study.
MCS: Nothing to disclose in the elaboration of this study.
ECA: Nothing to disclose in the elaboration of this study.
IC: Nothing to disclose in the elaboration of this study.
ASB: Nothing to disclose in the elaboration of this study.
TCT: Nothing to disclose in the elaboration of this study.
JMCM: Nothing to disclose in the elaboration of this study.
LFR: Nothing to disclose in the elaboration of this study.
JOU: Nothing to disclose in the elaboration of this study.