Contributions
Abstract: EP1390
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Multiple sclerosis (MS) is a disease with complex and not fully understood etiology and pathogenesis. Regardless of the new trends in MS research over the past decade, the clinical parameters remain crucial for diagnosis, physical disability assessment, follow up and prognosis of the disease progression.
Aim: to find predictors of increased physical disability and secondary progression in patients with relapsing remitting MS (RRMS).
Material and methods: 75 patients with RRMS were followed for 10 years period after diagnosis of MS. All subjects were on immunomodulatory therapy. The sample included 50 women and 25 men, aged 32 ± 8.7 years during the onset of the disease. The patient´s demographic characteristics, the presence of co-morbidity, the type of symptoms during the first and second attack (afferent, efferent and combined), the presence of mono- and polysymptomatic manifestations, the intervals between the first symptoms and the MS diagnosis, as well as between first and second attack, were analyzed.
Results: The baseline EDSS was 1.5±0.48. Within the 10-year period, 31 of the patients reached EDSS≥ 4 and 45% of them experienced secondary progression (EDSS 6). Based on the decision tree, we defined categorical variables (gender, mono/polysymtomatic manifestation, afferent/efferent symptoms during 1-rst and 2-nd relapse) and continuous variables (age at MS onset, the above mentioned time intervals) as predictors of obtaining EDSS ≥4. Through calculation of the predictive parameters we established a prognostic score for physical disability progression. The established score had specificity 82%, sensitivity 65%, positive predictive value 71% and negative predictive value 77%.
Conclusion: our study showed that the course of MS can be predicted with good accuracy based on early clinical signs, age at the disease onset and patient's gender. The introduced score could help reaching the individual therapeutic approach by providing directions for choosing appropriate immunomodulatory therapy.
Disclosure: Valentina Ignatova¹: The expenses for participation of Dr. V. Ignatova in ECRTIMS was covered by Ewopharma
Lyudmila Todorova²: nothing to disclose
Lyubomir Haralanov¹: nothing to disclose
Abstract: EP1390
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Multiple sclerosis (MS) is a disease with complex and not fully understood etiology and pathogenesis. Regardless of the new trends in MS research over the past decade, the clinical parameters remain crucial for diagnosis, physical disability assessment, follow up and prognosis of the disease progression.
Aim: to find predictors of increased physical disability and secondary progression in patients with relapsing remitting MS (RRMS).
Material and methods: 75 patients with RRMS were followed for 10 years period after diagnosis of MS. All subjects were on immunomodulatory therapy. The sample included 50 women and 25 men, aged 32 ± 8.7 years during the onset of the disease. The patient´s demographic characteristics, the presence of co-morbidity, the type of symptoms during the first and second attack (afferent, efferent and combined), the presence of mono- and polysymptomatic manifestations, the intervals between the first symptoms and the MS diagnosis, as well as between first and second attack, were analyzed.
Results: The baseline EDSS was 1.5±0.48. Within the 10-year period, 31 of the patients reached EDSS≥ 4 and 45% of them experienced secondary progression (EDSS 6). Based on the decision tree, we defined categorical variables (gender, mono/polysymtomatic manifestation, afferent/efferent symptoms during 1-rst and 2-nd relapse) and continuous variables (age at MS onset, the above mentioned time intervals) as predictors of obtaining EDSS ≥4. Through calculation of the predictive parameters we established a prognostic score for physical disability progression. The established score had specificity 82%, sensitivity 65%, positive predictive value 71% and negative predictive value 77%.
Conclusion: our study showed that the course of MS can be predicted with good accuracy based on early clinical signs, age at the disease onset and patient's gender. The introduced score could help reaching the individual therapeutic approach by providing directions for choosing appropriate immunomodulatory therapy.
Disclosure: Valentina Ignatova¹: The expenses for participation of Dr. V. Ignatova in ECRTIMS was covered by Ewopharma
Lyudmila Todorova²: nothing to disclose
Lyubomir Haralanov¹: nothing to disclose