Contributions
Abstract: EP1377
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Background: Balance and cognitive impairments are serious health concerns for persons with multiple sclerosis (MS, pwMS). Since majority of the studies have included pwMS with overt disability, association between cognition and balance in minimally disabled pwMS is not clear.
Aims: The aim was to investigate the association between cognitive functions and balance, fall risk, walking ability, balance confidence, depression and quality of life in pwMS with minimal disability using well-established measures and compare them with healthy controls (HC).
Methods: This study included 35 pwMS with the Expanded Disability Status Scale (EDSS) ≤ 3.0 and 39 HC. Cognitive functions were assessed using Brief International Cognitive Assessment for MS (BICAMS) that measures processing speed (Symbol Digit Modalities Test, SDMT), verbal (California Verbal Learning Test-2, CVLT2) and visuospatial (Brief Visuospatial Memory Test-Revised, BVMT-R) memory. Limits of stability (LOS- forward, backward, right, left, overall, test time), postural stability (PS- mediolateral, anteroposterior, overall) and fall risk (FR) were assessed with a posturography. The Brief-Balance Evaluation Systems Test (Brief-BESTest), Timed 25-Foot Walk Test (T25FW), 12-Item MS Walking Scale (MSWS-12), Activities-Specific Balance Confidence (ABC) Scale, Beck Depression Inventory (BDI), and MS International Quality of Life (MuSiQol) were also used.
Results: There were significant difference between the MS and HC in all domains of balance, gait and cognitive functions (p< 0.05). In MS group, SDMT was significantly correlated with the LOS test time, LOS overall, LOS posterior, PS overall, PS mediolateral, FR, Brief-BESTest, T25FW (r=-0.370, 0.380, 0.460, -0.350, -0.397, -0.488, 0.463, -0.537, p< 0.05). BVMT-R was significantly correlated with LOS test time, mediolateral PS, FR, Brief-BESTest, T25FW (r=-0.409, -0.371, -0.494, 0.471, -0.359, p< 0.05). CVLT was only correlated with Brief-BESTest total and biomechanical limitations sub-score (r=0.389, 0.473; p=0.021, 0.004). EDSS, MSWS-12, ABC, BDI, and MuSiQol were not correlated with BICAMS scores.
Conclusions: İnformation processing speed and visuospatial memory are highly associated with balance in minimally disabled pwMS independently of disability degree. Although Brief-BESTest was correlated with all cognitive domains including processing speed, verbal-auditory and visual memory, posturography was not correlated with the verbal-auditory memory.
Disclosure: Hatice AYAN: Nothing to disclose. Ozge ERTEKIN: Nothing to disclose.
Turhan KAHRAMAN: Nothing to disclose. Pinar YIGIT: Nothing to disclose.
Serkan OZAKBAS: Nothing to disclose
Abstract: EP1377
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Background: Balance and cognitive impairments are serious health concerns for persons with multiple sclerosis (MS, pwMS). Since majority of the studies have included pwMS with overt disability, association between cognition and balance in minimally disabled pwMS is not clear.
Aims: The aim was to investigate the association between cognitive functions and balance, fall risk, walking ability, balance confidence, depression and quality of life in pwMS with minimal disability using well-established measures and compare them with healthy controls (HC).
Methods: This study included 35 pwMS with the Expanded Disability Status Scale (EDSS) ≤ 3.0 and 39 HC. Cognitive functions were assessed using Brief International Cognitive Assessment for MS (BICAMS) that measures processing speed (Symbol Digit Modalities Test, SDMT), verbal (California Verbal Learning Test-2, CVLT2) and visuospatial (Brief Visuospatial Memory Test-Revised, BVMT-R) memory. Limits of stability (LOS- forward, backward, right, left, overall, test time), postural stability (PS- mediolateral, anteroposterior, overall) and fall risk (FR) were assessed with a posturography. The Brief-Balance Evaluation Systems Test (Brief-BESTest), Timed 25-Foot Walk Test (T25FW), 12-Item MS Walking Scale (MSWS-12), Activities-Specific Balance Confidence (ABC) Scale, Beck Depression Inventory (BDI), and MS International Quality of Life (MuSiQol) were also used.
Results: There were significant difference between the MS and HC in all domains of balance, gait and cognitive functions (p< 0.05). In MS group, SDMT was significantly correlated with the LOS test time, LOS overall, LOS posterior, PS overall, PS mediolateral, FR, Brief-BESTest, T25FW (r=-0.370, 0.380, 0.460, -0.350, -0.397, -0.488, 0.463, -0.537, p< 0.05). BVMT-R was significantly correlated with LOS test time, mediolateral PS, FR, Brief-BESTest, T25FW (r=-0.409, -0.371, -0.494, 0.471, -0.359, p< 0.05). CVLT was only correlated with Brief-BESTest total and biomechanical limitations sub-score (r=0.389, 0.473; p=0.021, 0.004). EDSS, MSWS-12, ABC, BDI, and MuSiQol were not correlated with BICAMS scores.
Conclusions: İnformation processing speed and visuospatial memory are highly associated with balance in minimally disabled pwMS independently of disability degree. Although Brief-BESTest was correlated with all cognitive domains including processing speed, verbal-auditory and visual memory, posturography was not correlated with the verbal-auditory memory.
Disclosure: Hatice AYAN: Nothing to disclose. Ozge ERTEKIN: Nothing to disclose.
Turhan KAHRAMAN: Nothing to disclose. Pinar YIGIT: Nothing to disclose.
Serkan OZAKBAS: Nothing to disclose