Contributions
Abstract: EP1376
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: It has been shown that the tongue somatosensory evoked potentials (tSSEP) are able to detect afferent trigeminal system involvement in people with clinically isolated syndrome (pwCIS), regardless of the MRI results. The aim of this study was to investigate the evolution of trigeminal afferent system involvement, measured by tSSEP, in pwCIS over the two-year follow-up.
Methods: 115 pwCIS (80 females, mean age 32.12±8.62, median EDSS 1 (0 - 3.5)) performed tSSEP at baseline and 75 after two-year follow-up. Latency of the component P1 and amplitude P1_N1 were analyzed. The tSSEP score was calculated from the raw tSSEP data according to cut-off values for absent response and prolonged latency of the main component, P1 (0 = normal response, 1 = prolonged latency, 2 = irregular morphology, 3 = absent response). It was calculated separately for the left (left tSSEP) and the right side (right tSSEP) and the two values were summed.
Results: Baseline median tSSEP score was 1 (range 0-6) (median left tSSEP score 0 (0-3) and median right tSSEP score 0 (0-3)). After two years, median tSSEP score was 3 (range 0-6) (median left tSSEP score 2 (0-3) and median right tSSEP score 2 (0-3)). This worsening of tSSEP score (including both right and left tSSEP score) after two-year follow-up was statistically significant, p< 0.001 (p=0.004 and p=0.001, respectively). Out of 75 patients with all data available for analysis, conduction block was present in 6 patients at baseline and 20 patients after two years on the right side (p=0.004), and 11 patients at baseline and 26 patients after two years on the left side (p=0.003).
Conclusion: Substantial proportion of pwCIS experience worsening of tSSEP over 24 months of follow-up.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622.
Tereza Gabelić: nothing to disclose
Luka Crnošija: nothing to disclose
Barbara Barun: nothing to disclose
Ivan Adamec: nothing to disclose
Ivan Pavlović: nothing to disclose
Magdalena Krbot Skorić: nothing to disclose
Mario Habek: nothing to disclose
Abstract: EP1376
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: It has been shown that the tongue somatosensory evoked potentials (tSSEP) are able to detect afferent trigeminal system involvement in people with clinically isolated syndrome (pwCIS), regardless of the MRI results. The aim of this study was to investigate the evolution of trigeminal afferent system involvement, measured by tSSEP, in pwCIS over the two-year follow-up.
Methods: 115 pwCIS (80 females, mean age 32.12±8.62, median EDSS 1 (0 - 3.5)) performed tSSEP at baseline and 75 after two-year follow-up. Latency of the component P1 and amplitude P1_N1 were analyzed. The tSSEP score was calculated from the raw tSSEP data according to cut-off values for absent response and prolonged latency of the main component, P1 (0 = normal response, 1 = prolonged latency, 2 = irregular morphology, 3 = absent response). It was calculated separately for the left (left tSSEP) and the right side (right tSSEP) and the two values were summed.
Results: Baseline median tSSEP score was 1 (range 0-6) (median left tSSEP score 0 (0-3) and median right tSSEP score 0 (0-3)). After two years, median tSSEP score was 3 (range 0-6) (median left tSSEP score 2 (0-3) and median right tSSEP score 2 (0-3)). This worsening of tSSEP score (including both right and left tSSEP score) after two-year follow-up was statistically significant, p< 0.001 (p=0.004 and p=0.001, respectively). Out of 75 patients with all data available for analysis, conduction block was present in 6 patients at baseline and 20 patients after two years on the right side (p=0.004), and 11 patients at baseline and 26 patients after two years on the left side (p=0.003).
Conclusion: Substantial proportion of pwCIS experience worsening of tSSEP over 24 months of follow-up.
Disclosure: Funding: Croatian Science Foundation grant HRZZ UIP-11-2013-2622.
Tereza Gabelić: nothing to disclose
Luka Crnošija: nothing to disclose
Barbara Barun: nothing to disclose
Ivan Adamec: nothing to disclose
Ivan Pavlović: nothing to disclose
Magdalena Krbot Skorić: nothing to disclose
Mario Habek: nothing to disclose