Contributions
Abstract: EP1373
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Several studies have shown that bone mineral density (BMD) at the femoral neck decreases with increasing physical handicap in MS patients. BMD measurements in an unselected group of 80 fully ambulatory persons with MS aged 19-50 years revealed osteopenia in 12 and osteoporosis in two participants in 2008. We report findings at ten-year follow-up in 2018.
Methods: Examinations performed in February and March 2018 included BMD, measures of physical functioning, and serum 25(OH) vitamin D measurements.
Results: Of 78 persons still alive, 70 participated (73 % women). The number of patients with normal BMD both at the hip (mean total hip) and in the lumbar spine (L1-L4) decreased from 56 (80 %) to 50 (71 %). The number of persons with osteoporosis increased from 2 to 6 (t-score ≤ -2,5 one or both sites), and the number of individuals with osteopenia from 12 to 14 (t-score -1,5 to -2,49 one or both sites) (Pearson Chi-Square < 0.001[KM1] ).
Reduced ambulatory function was associated with osteopenia and osteoporosis (Pearson Chi-Square 0.005).
From 2008 to 2018 the proportion of participants with optimal 25(OH) vitamin D values (≥ 75 nmol/L) at the end of winter increased from 14 to 50%, and the proportion with insufficient levels (< 50 nmol/L) decreased from 36 to 19%.
Conclusions: Preliminary analyses show a statistically significant increase in the proportion of persons with osteopenia and osteoporosis over a 10-year period. Linear regression analysis will be applied to estimate the effects of known predictors of BMD. The proportion of patients with vitamin D levels considered optimal for persons with MS and bone health has increased.
Persons with MS should be routinely screened for osteoporosis.
Disclosure: Funding: University Hospital of North Norway
Kampman; nothing to disclose.
Steffensen: nothing to disclose.
Mellgren: nothing to disclose.
Jørgensen: nothing to disclose.
Abstract: EP1373
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Several studies have shown that bone mineral density (BMD) at the femoral neck decreases with increasing physical handicap in MS patients. BMD measurements in an unselected group of 80 fully ambulatory persons with MS aged 19-50 years revealed osteopenia in 12 and osteoporosis in two participants in 2008. We report findings at ten-year follow-up in 2018.
Methods: Examinations performed in February and March 2018 included BMD, measures of physical functioning, and serum 25(OH) vitamin D measurements.
Results: Of 78 persons still alive, 70 participated (73 % women). The number of patients with normal BMD both at the hip (mean total hip) and in the lumbar spine (L1-L4) decreased from 56 (80 %) to 50 (71 %). The number of persons with osteoporosis increased from 2 to 6 (t-score ≤ -2,5 one or both sites), and the number of individuals with osteopenia from 12 to 14 (t-score -1,5 to -2,49 one or both sites) (Pearson Chi-Square < 0.001[KM1] ).
Reduced ambulatory function was associated with osteopenia and osteoporosis (Pearson Chi-Square 0.005).
From 2008 to 2018 the proportion of participants with optimal 25(OH) vitamin D values (≥ 75 nmol/L) at the end of winter increased from 14 to 50%, and the proportion with insufficient levels (< 50 nmol/L) decreased from 36 to 19%.
Conclusions: Preliminary analyses show a statistically significant increase in the proportion of persons with osteopenia and osteoporosis over a 10-year period. Linear regression analysis will be applied to estimate the effects of known predictors of BMD. The proportion of patients with vitamin D levels considered optimal for persons with MS and bone health has increased.
Persons with MS should be routinely screened for osteoporosis.
Disclosure: Funding: University Hospital of North Norway
Kampman; nothing to disclose.
Steffensen: nothing to disclose.
Mellgren: nothing to disclose.
Jørgensen: nothing to disclose.