Contributions
Abstract: EP1369
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS and gender
It has been reported that estrogen may affect the level of Th-1 / Th-2 lymphocytes and ratio of Th-1 and Th-2 that play an important role in immunopathogenesis in multiple sclerosis (MS). Therefore hormonal changes during transitional periods such as pregnancy and menopause may affect the activity of the disease at different phases of the menstrual cycle.
The aim of this study is to determine the association of women with MS with variables such as menarche age, menstrual order and menopausal age and disease-related factors such as disability level and a number of attacks.
This descriptive study enrolled 281 person with MS (pwMS). The participants were evaluated by a simple and short survey by the researchers. Expanded Disability Status Scale (EDSS) score, number of attacks and disease duration evaluated by a neurologist.
Sixty-seven (23.8%) of total 281 patients entered menopause. There is no significant difference in the terms of EDSS score of pwMS with or without menopause (p>0.05). Sixty patients (21.4%) had children after MS. There is no significant difference between pre-post child and number of attacks, post child and current EDSS scores of these pwMS (p>0.05). It was found that 80.4% of the patients had a regular menstrual cycle while 19.6% patients were irregular. The EDSS score was significantly higher in women with irregular menstruation cycle than women with regular menstruation cycle (p< 0.05). There is a significant difference between the average age of Turkey menarche (13.3) and the average age of menarche of women with MS (13.07) (p< 0.05).
This study has suggested that menopause and childbearing may not affect disability level or a number of attacks women with MS. On the other hand, women with MS has an earlier age of menarche and this could be linked with an increased risk of MS or with an earlier age at MS symptom onset.
Disclosure: Serkan Ozakbas: nothing to disclose
İlknur Hosgel: nothing to disclose
Asiye Tuba Ozdogar: nothing to disclose
Abstract: EP1369
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS and gender
It has been reported that estrogen may affect the level of Th-1 / Th-2 lymphocytes and ratio of Th-1 and Th-2 that play an important role in immunopathogenesis in multiple sclerosis (MS). Therefore hormonal changes during transitional periods such as pregnancy and menopause may affect the activity of the disease at different phases of the menstrual cycle.
The aim of this study is to determine the association of women with MS with variables such as menarche age, menstrual order and menopausal age and disease-related factors such as disability level and a number of attacks.
This descriptive study enrolled 281 person with MS (pwMS). The participants were evaluated by a simple and short survey by the researchers. Expanded Disability Status Scale (EDSS) score, number of attacks and disease duration evaluated by a neurologist.
Sixty-seven (23.8%) of total 281 patients entered menopause. There is no significant difference in the terms of EDSS score of pwMS with or without menopause (p>0.05). Sixty patients (21.4%) had children after MS. There is no significant difference between pre-post child and number of attacks, post child and current EDSS scores of these pwMS (p>0.05). It was found that 80.4% of the patients had a regular menstrual cycle while 19.6% patients were irregular. The EDSS score was significantly higher in women with irregular menstruation cycle than women with regular menstruation cycle (p< 0.05). There is a significant difference between the average age of Turkey menarche (13.3) and the average age of menarche of women with MS (13.07) (p< 0.05).
This study has suggested that menopause and childbearing may not affect disability level or a number of attacks women with MS. On the other hand, women with MS has an earlier age of menarche and this could be linked with an increased risk of MS or with an earlier age at MS symptom onset.
Disclosure: Serkan Ozakbas: nothing to disclose
İlknur Hosgel: nothing to disclose
Asiye Tuba Ozdogar: nothing to disclose