Contributions
Abstract: EP1365
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS and gender
Introduction: There are quite contradictory data on protective role of exclusive breastfeeding. When deciding to continue breastfeeding, the main therapy of MS will be postponed. This can negatively affect on the activity of disease.
Objective: to evaluate role of breastfeeding on postpartum relapses.
Methods: A retrospective analysis from 2011 to 2017 of SPbMS Center registry was performed. For the analysis, the data were selected during observation for 1 year after delivery and without the use of 2-line drugs during pregnancy and the first months after childbirth. Various characteristics of the impact of the cardinal exacerbations were assessed: gynecological history, fertility, anesthesia, gestational age, MRI data before and after pregnancy, pre-pregnancy therapy, total lactation duration, and duration of exclusive breastfeeding. Statistical analysis was performed with the program GraphPad Prism v7.0.
Results: 127 women (133 births) were enrolled in the study. In 43% of cases there were exacerbations in the first year after birth with a median at 2.5 months/There was a weak negative correlation with the age of onset (p = 0.0039), age of diagnosis of MS (p = 0.0011) and the probability of exacerbations after childbirth. When assessing gynecological history data, none of the correlation parameters was obtained (the presence of abortions, prior births, cesarean section or the use of anesthesia during labor). Also, there was no correlation with the gestational age of infants. The presence of lactation and the duration of exclusive breastfeeding did not correlate with the likelihood of exacerbations. Most patients with exacerbations (90.5%) and without exacerbations after childbirth (95.6%) started breastfeeding. The duration of exclusive breastfeeding was approximately the same in the two groups, but there was a difference in the total lactation time (p = 0.013). There was no correlation of exacerbations after childbirth with the duration MS treatment and any MS injectable medicine (interferons and glatiramera acetate).
Conclusion: Exclusive breastfeeding did not reduce the frequency of exacerbations after childbirth (p = 0.249).
Disclosure: M Shumilina: Has recieved and dedicated to research support fees for board membership, consultancy or speaking, or grants, in the last 3 years from Novartis, Biocad, Sanofi/Genzyme, Roche, Johnson & Johnson/ Janssen, R-Pharm and Generium.
E Evdoshenko: Has recieved and dedicated to research support fees for board membership, consultancy or speaking, or grants, in the last 3 years from Biogen Idec, Sanofi, Genzyme and Generium.
E Kairbekova: nothing to disclose.
A Skoromets: nothing to disclose.
Abstract: EP1365
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS and gender
Introduction: There are quite contradictory data on protective role of exclusive breastfeeding. When deciding to continue breastfeeding, the main therapy of MS will be postponed. This can negatively affect on the activity of disease.
Objective: to evaluate role of breastfeeding on postpartum relapses.
Methods: A retrospective analysis from 2011 to 2017 of SPbMS Center registry was performed. For the analysis, the data were selected during observation for 1 year after delivery and without the use of 2-line drugs during pregnancy and the first months after childbirth. Various characteristics of the impact of the cardinal exacerbations were assessed: gynecological history, fertility, anesthesia, gestational age, MRI data before and after pregnancy, pre-pregnancy therapy, total lactation duration, and duration of exclusive breastfeeding. Statistical analysis was performed with the program GraphPad Prism v7.0.
Results: 127 women (133 births) were enrolled in the study. In 43% of cases there were exacerbations in the first year after birth with a median at 2.5 months/There was a weak negative correlation with the age of onset (p = 0.0039), age of diagnosis of MS (p = 0.0011) and the probability of exacerbations after childbirth. When assessing gynecological history data, none of the correlation parameters was obtained (the presence of abortions, prior births, cesarean section or the use of anesthesia during labor). Also, there was no correlation with the gestational age of infants. The presence of lactation and the duration of exclusive breastfeeding did not correlate with the likelihood of exacerbations. Most patients with exacerbations (90.5%) and without exacerbations after childbirth (95.6%) started breastfeeding. The duration of exclusive breastfeeding was approximately the same in the two groups, but there was a difference in the total lactation time (p = 0.013). There was no correlation of exacerbations after childbirth with the duration MS treatment and any MS injectable medicine (interferons and glatiramera acetate).
Conclusion: Exclusive breastfeeding did not reduce the frequency of exacerbations after childbirth (p = 0.249).
Disclosure: M Shumilina: Has recieved and dedicated to research support fees for board membership, consultancy or speaking, or grants, in the last 3 years from Novartis, Biocad, Sanofi/Genzyme, Roche, Johnson & Johnson/ Janssen, R-Pharm and Generium.
E Evdoshenko: Has recieved and dedicated to research support fees for board membership, consultancy or speaking, or grants, in the last 3 years from Biogen Idec, Sanofi, Genzyme and Generium.
E Kairbekova: nothing to disclose.
A Skoromets: nothing to disclose.