Contributions
Abstract: EP1346
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Mastery is the sense of being in control of one's life. Improvement in mastery may help to improve quality of life, the pathway potentially being through stress modulation or greater utilisation of healthy lifestyle behaviours known to improve outcomes in MS. Despite this, there is a relative paucity of research in this area, both in terms of the determinants of mastery in people with MS and its association with quality of life.
Objective: To explore the association between mastery and health-related quality of life (HRQOL) in people with multiple sclerosis.
Method: Two cross-sectional samples of adults with MS (n=1,401 & n=573), recruited through convenience sampling, completed an online survey which measured mastery using the Pearlin Mastery Scale (PMS; range 14-28), physical and mental HRQOL (both range 0-100) via the physical and mental composite scores of the MSQOL-54, along with other covariates, including demographics, clinical characteristics and lifestyle factors. Associations between mastery and HRQOL were assessed using linear regression, adjusted for age, sex, disability, fatigue and depression.
Results: Greater mastery score was associated with significantly higher physical and mental HRQOL in both samples, such that a one-point increase in the PMS was associated with a 1.75 (p< 0.001) and 1.80 (p< 0.001) rise in physical HRQOL in the two samples, and a 1.54 (p< 0.001) and 1.66 (p< 0.001) increase in mental HRQOL in the two samples, all associations highly robust to adjustment. A strong dose-dependent relationship was demonstrated between a quartile categorical mastery variable and both physical and mental HRQOL (ptrend< 0.001 for all models). Mastery was significantly related with all subscores of both physical and mental HRQOL, with similar magnitudes of associations demonstrated between subscores.
Conclusions: These results provide initial evidence that greater mastery is associated with a better quality of life, both physical and mental, with replication in a separately recruited cohort. Efforts to improve patients' sense of self control and agency may have benefits for their quality of life, even despite clinical features of their MS.
Disclosure: The study was funded by the Bloom Foundation, Wal Pisciotta, and the Horne Family Charitable Trust.
EO´K: nothing to disclose.
AMDL: nothing to disclose.
SSJ: nothing to disclose.
GAJ receives royalties for his books, Overcoming Multiple Sclerosis and Recovering from Multiple Sclerosis, and has received remuneration for conducting lifestyle educational workshops for people with MS.
SN has received remuneration for conducting lifestyle educational workshops for people with MS.
WB: nothing to disclose.
KLT has received remuneration for conducting lifestyle educational workshops for people with MS.
CRB: nothing to disclose.
TJW: nothing to disclose.
Abstract: EP1346
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Mastery is the sense of being in control of one's life. Improvement in mastery may help to improve quality of life, the pathway potentially being through stress modulation or greater utilisation of healthy lifestyle behaviours known to improve outcomes in MS. Despite this, there is a relative paucity of research in this area, both in terms of the determinants of mastery in people with MS and its association with quality of life.
Objective: To explore the association between mastery and health-related quality of life (HRQOL) in people with multiple sclerosis.
Method: Two cross-sectional samples of adults with MS (n=1,401 & n=573), recruited through convenience sampling, completed an online survey which measured mastery using the Pearlin Mastery Scale (PMS; range 14-28), physical and mental HRQOL (both range 0-100) via the physical and mental composite scores of the MSQOL-54, along with other covariates, including demographics, clinical characteristics and lifestyle factors. Associations between mastery and HRQOL were assessed using linear regression, adjusted for age, sex, disability, fatigue and depression.
Results: Greater mastery score was associated with significantly higher physical and mental HRQOL in both samples, such that a one-point increase in the PMS was associated with a 1.75 (p< 0.001) and 1.80 (p< 0.001) rise in physical HRQOL in the two samples, and a 1.54 (p< 0.001) and 1.66 (p< 0.001) increase in mental HRQOL in the two samples, all associations highly robust to adjustment. A strong dose-dependent relationship was demonstrated between a quartile categorical mastery variable and both physical and mental HRQOL (ptrend< 0.001 for all models). Mastery was significantly related with all subscores of both physical and mental HRQOL, with similar magnitudes of associations demonstrated between subscores.
Conclusions: These results provide initial evidence that greater mastery is associated with a better quality of life, both physical and mental, with replication in a separately recruited cohort. Efforts to improve patients' sense of self control and agency may have benefits for their quality of life, even despite clinical features of their MS.
Disclosure: The study was funded by the Bloom Foundation, Wal Pisciotta, and the Horne Family Charitable Trust.
EO´K: nothing to disclose.
AMDL: nothing to disclose.
SSJ: nothing to disclose.
GAJ receives royalties for his books, Overcoming Multiple Sclerosis and Recovering from Multiple Sclerosis, and has received remuneration for conducting lifestyle educational workshops for people with MS.
SN has received remuneration for conducting lifestyle educational workshops for people with MS.
WB: nothing to disclose.
KLT has received remuneration for conducting lifestyle educational workshops for people with MS.
CRB: nothing to disclose.
TJW: nothing to disclose.