Contributions
Abstract: EP1340
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Multiple sclerosis (MS) is associated with an increased risk of developing physical, cognitive and mental health problems. Current studies have demonstrated an adverse association between parental MS mental health problems and their offspring's mental health development.
Objective/aim: The purpose of this study was to investigate whether the maternal multiple sclerosis is associated with mental health status of their child.
Methods: Data from the Danish National Birth Cohort (DNBC) were merged with information from the Danish Multiple Sclerosis Registry. Two proxies - total difficulties score and prediction of any psychiatric diagnosis, based on the Strength and Difficulties Questionnaire, were used to measure mental health status of the children.
Results: For the total difficulties score the control and exposed group consisted of respectively 42,016 children of mothers without MS and 40 children of mothers with MS. For the prediction of any psychiatric diagnosis, 16,829 children of mothers without MS were in the control group and 17 children in the exposed group. We found no statistical significant association between maternal MS and mental health status on neither of the proxies.
Discussion: Unlike previous studies, it seems that in our cohort maternal MS is not associated with mental health status of the children up to age 11. However, we did not have information about maternal mental health status, which in other studies shows a mediating effect on mental health status of their children, and it may be that participation of more resourceful women in the DNBC favours our results.
Conclusion: Maternal multiple sclerosis showed no association with mental health status of their children at age eleven.
Disclosure: Johanna Balslev Andersen:
J.B.A.: nothing to disclose.
Julie Yoon Moberg:
J.Y. Moberg has received travel and educational grants from Biogen Denmark A/S, Merck A/S, Roche Pharmaceuticals A/S, Sanofi Genzyme Denmark and Teva Denmark A/S and has acted as a speaker for Biogen Denmark A/S, Sanofi Genzyme Denmark, and Teva Denmark A/S.
Janni Niclasen J.N.: nothing to disclose.
Bjarne Laursen
B.L.: nothing to disclose.
Melinda Magyari
M.M. has served on scientific advisory board for Biogen, Sanofi, Teva, Roche, Novartis, Merck, has received honoraria for lecturing from Biogen, Merck, Novartis, Sanofi, has received support for congress participation from Biogen, Genzyme, Teva, Roche.
Abstract: EP1340
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Multiple sclerosis (MS) is associated with an increased risk of developing physical, cognitive and mental health problems. Current studies have demonstrated an adverse association between parental MS mental health problems and their offspring's mental health development.
Objective/aim: The purpose of this study was to investigate whether the maternal multiple sclerosis is associated with mental health status of their child.
Methods: Data from the Danish National Birth Cohort (DNBC) were merged with information from the Danish Multiple Sclerosis Registry. Two proxies - total difficulties score and prediction of any psychiatric diagnosis, based on the Strength and Difficulties Questionnaire, were used to measure mental health status of the children.
Results: For the total difficulties score the control and exposed group consisted of respectively 42,016 children of mothers without MS and 40 children of mothers with MS. For the prediction of any psychiatric diagnosis, 16,829 children of mothers without MS were in the control group and 17 children in the exposed group. We found no statistical significant association between maternal MS and mental health status on neither of the proxies.
Discussion: Unlike previous studies, it seems that in our cohort maternal MS is not associated with mental health status of the children up to age 11. However, we did not have information about maternal mental health status, which in other studies shows a mediating effect on mental health status of their children, and it may be that participation of more resourceful women in the DNBC favours our results.
Conclusion: Maternal multiple sclerosis showed no association with mental health status of their children at age eleven.
Disclosure: Johanna Balslev Andersen:
J.B.A.: nothing to disclose.
Julie Yoon Moberg:
J.Y. Moberg has received travel and educational grants from Biogen Denmark A/S, Merck A/S, Roche Pharmaceuticals A/S, Sanofi Genzyme Denmark and Teva Denmark A/S and has acted as a speaker for Biogen Denmark A/S, Sanofi Genzyme Denmark, and Teva Denmark A/S.
Janni Niclasen J.N.: nothing to disclose.
Bjarne Laursen
B.L.: nothing to disclose.
Melinda Magyari
M.M. has served on scientific advisory board for Biogen, Sanofi, Teva, Roche, Novartis, Merck, has received honoraria for lecturing from Biogen, Merck, Novartis, Sanofi, has received support for congress participation from Biogen, Genzyme, Teva, Roche.