Contributions
Abstract: EP1338
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Natural course
Background: The identification of predictors of long-term prognosis is a major concern in early phase of the disease and is a purpose of treatment optimisation at individual level.
Objectives: To identify long-term disability predictors in initial brain MRI and relation with history of suggestive event
Methods: A cohort of clinically isolated syndromes with a first documented event that occurred more than 14 years ago was analysed. Suggestive event was systematically screened. The Initial brain MRI was analysed by 2 readers to determine the number of T2 and gadolinium enhanced lesions. The outcome measure was time to reach EDSS 3 and 6. The explicative variables were, suggestive event (yes / no) , T2 lesions ( n ≥ 14 / < 14), gadolinium lesions (n ≥ 2 / < 2). Cut-off for number of T2 and gadolinium lesions were determined by ROC curve. A univariate survival analyse was performed to assess each variable regarding the time to reach EDSS 3 and 6. A cox model was used for multivariate analysis.
Results: 227 patients with available brain MRI data and a median follow up of 13.5 years (6.53-15.5) have been analysed. Median age at onset was 31.1 years (11.8 -66.4) with 70% of women. A suggestive event supported by MRI lesion was presented in 26.8% of cases. A second relapse occurred in 60% of patients and 70% fulfilled McDonald 2010 MS criteria at the end of follow-up. The mean number of brain T2 and gadolinium lesions at baseline were 9.2 ±8.9 and 1.41 ±2.7 respectively. The proportion of patients who reached an EDSS 3 and 6 were not significantly different depending on gadolinium lesions and history of suggestive event. Conversely a number of T2 lesions ≥ 14 increases the risk to reach EDSS 3 (p = 0.009), data confirmed by multivariable analysis (p = 0.014).
Conclusion: A high T2 lesion load independently increases the risk of long-term disability
Disclosure: Dr A Gueguen has received speaking honoraria from Sanofi Genzyme, Roche, serves on scientific boards for Novartis, Merck, Roche, Mylan and received travel expenses for participation in scientific meeting from Roche, Teva, Sanofi-Genzyme
Abstract: EP1338
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Natural course
Background: The identification of predictors of long-term prognosis is a major concern in early phase of the disease and is a purpose of treatment optimisation at individual level.
Objectives: To identify long-term disability predictors in initial brain MRI and relation with history of suggestive event
Methods: A cohort of clinically isolated syndromes with a first documented event that occurred more than 14 years ago was analysed. Suggestive event was systematically screened. The Initial brain MRI was analysed by 2 readers to determine the number of T2 and gadolinium enhanced lesions. The outcome measure was time to reach EDSS 3 and 6. The explicative variables were, suggestive event (yes / no) , T2 lesions ( n ≥ 14 / < 14), gadolinium lesions (n ≥ 2 / < 2). Cut-off for number of T2 and gadolinium lesions were determined by ROC curve. A univariate survival analyse was performed to assess each variable regarding the time to reach EDSS 3 and 6. A cox model was used for multivariate analysis.
Results: 227 patients with available brain MRI data and a median follow up of 13.5 years (6.53-15.5) have been analysed. Median age at onset was 31.1 years (11.8 -66.4) with 70% of women. A suggestive event supported by MRI lesion was presented in 26.8% of cases. A second relapse occurred in 60% of patients and 70% fulfilled McDonald 2010 MS criteria at the end of follow-up. The mean number of brain T2 and gadolinium lesions at baseline were 9.2 ±8.9 and 1.41 ±2.7 respectively. The proportion of patients who reached an EDSS 3 and 6 were not significantly different depending on gadolinium lesions and history of suggestive event. Conversely a number of T2 lesions ≥ 14 increases the risk to reach EDSS 3 (p = 0.009), data confirmed by multivariable analysis (p = 0.014).
Conclusion: A high T2 lesion load independently increases the risk of long-term disability
Disclosure: Dr A Gueguen has received speaking honoraria from Sanofi Genzyme, Roche, serves on scientific boards for Novartis, Merck, Roche, Mylan and received travel expenses for participation in scientific meeting from Roche, Teva, Sanofi-Genzyme