Contributions
Abstract: EP1336
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Natural course
Introduction: Asymptomatic white matter lesions are frequently encountered due tothe widespread use of magnetic resonance imaging (MRI). Patients with lesions that suggest multiple sclerosis (MS) without a clinical event are definedas radiologically isolated syndrome (RIS). The identification of risk factors for conversion to multiple sclerosis (MS) is important for early diagnosis.
Objective: Our study aims to determine predictive factors ofconversion from RIS to MS.
Methods: We collected data ofpatients with RIS including demographic features, radiological data such as number and location of lesions, contrast enhancement,andoligoclonal band status.We calculated the timeto conversion to MS and determined the effect of the predictors usinglog-rank test.
Results: Eighty-one patients (58 female, 23 male) who met the RIS criteria were included in our study.The mean follow-up duration was 2.2 (±2.3) years.Of 81 patients, 15 (18.5%) had a clinical attack and diagnosed with MS. Presence of cervical spinal lesions (log-rank test; p=0.027), brain stem lesions (log-rank test; p=0.048), and oligoclonal bandstatus (log-rank test; p=0.005) predicted a higher conversion rate. On the other hand, gender, T2 lesion count, family history, smoking, and pregnancy status did not increase the risk of conversion to MS(log-rank test; p>0.05).
Conclusions: Our study confirms previous studies on RIS. The presenceof the oligoclonal bands, brainstem and cervical spinal lesions increasethe risk of MS considerably. However, larger prospective studies are neededto define the effect of other possible predictors with marginalimpact on conversion to MS.
Disclosure: İrem Çiftçi: nothing to disclose,Tuncay Gündüz: nothing to disclose,Murat Kürtüncü: nothing to disclose, Mefküre Eraksoy: nothing to disclose
Abstract: EP1336
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Natural course
Introduction: Asymptomatic white matter lesions are frequently encountered due tothe widespread use of magnetic resonance imaging (MRI). Patients with lesions that suggest multiple sclerosis (MS) without a clinical event are definedas radiologically isolated syndrome (RIS). The identification of risk factors for conversion to multiple sclerosis (MS) is important for early diagnosis.
Objective: Our study aims to determine predictive factors ofconversion from RIS to MS.
Methods: We collected data ofpatients with RIS including demographic features, radiological data such as number and location of lesions, contrast enhancement,andoligoclonal band status.We calculated the timeto conversion to MS and determined the effect of the predictors usinglog-rank test.
Results: Eighty-one patients (58 female, 23 male) who met the RIS criteria were included in our study.The mean follow-up duration was 2.2 (±2.3) years.Of 81 patients, 15 (18.5%) had a clinical attack and diagnosed with MS. Presence of cervical spinal lesions (log-rank test; p=0.027), brain stem lesions (log-rank test; p=0.048), and oligoclonal bandstatus (log-rank test; p=0.005) predicted a higher conversion rate. On the other hand, gender, T2 lesion count, family history, smoking, and pregnancy status did not increase the risk of conversion to MS(log-rank test; p>0.05).
Conclusions: Our study confirms previous studies on RIS. The presenceof the oligoclonal bands, brainstem and cervical spinal lesions increasethe risk of MS considerably. However, larger prospective studies are neededto define the effect of other possible predictors with marginalimpact on conversion to MS.
Disclosure: İrem Çiftçi: nothing to disclose,Tuncay Gündüz: nothing to disclose,Murat Kürtüncü: nothing to disclose, Mefküre Eraksoy: nothing to disclose