Contributions
Abstract: EP1326
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Paediatric MS
Introduction: Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating CNS disease and is one of the most common causes of disability in young people. In the diagnosis of MS, endo- and exogenous evoked potentials are widely used. The aim of the study was the neurophysiological characteristics of patients with relapsing-remitting MS qualified for interferon treatment.
Material and methods: The study included 22 children aged 11.5-17 years (mean 14.5) hospitalized with newly diagnosed multiple sclerosis, hospitalized in 2016-2018 in the University Children´s Hospital in Krakow. According to the type of the first clinical symptoms, children were divided into three groups. Group I consisted of 11 children with visual impairment, group II of 7 children with sensory and motor abnormalities, while in group III there were 4 children with impaired vision and sensation. In all children, in the initial diagnostic process, exogenous evoked potentials (VEP,BAEP,SEP) and endogenous evoked P300 potential were made.
Results: In the VEP study, elongated P100 latencies in all patients, P100 amplitude was normal in 20 children and in 2 was decrease. In the BAEP examination, normal latencies and interlatencies of waves I-III, III-V, I-V in all children was obtained. At the median nerve, slightly elongated latency N9 was obtained in group I-9.62+/-0.81ms, in group II-9.76+/0.75ms, in group III-9.41+/-0.81ms, P14 in group I-14.46+/-1.25ms, N18 in group III 18.43+/-1.3ms, N20 was normal in all groups. In the study of endogenous potentials, a slight elongation of the P300 latency in group I-332.55+/-26.70ms and, in group II-327.43+/-17.70ms, in the group III- 329.75+/-21.86ms, and a reduced amplitude in group II-2.37+/-4.82uV, compared to the control group.
Conclusions:
1. VEP is a sensitive neurophysiological method in the objective assessment of retrobulbar optic neuritis, and in clinically silent optic pathways involvement
2. The integrity of the auditory pathway in children with MS at the early onset of the disease remains unaffected
3. The prolongation of the latency of waves in the SEP study corresponds to the clinical symptoms
4. The prolongation of P300 latency may indicate a cognitive impairment in children with newly diagnosed MS
Disclosure: Witek : I have nothing to disclose
Kroczka: I have nothing to disclose
Stolarska: I have nothing to disclose
Abstract: EP1326
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Paediatric MS
Introduction: Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating CNS disease and is one of the most common causes of disability in young people. In the diagnosis of MS, endo- and exogenous evoked potentials are widely used. The aim of the study was the neurophysiological characteristics of patients with relapsing-remitting MS qualified for interferon treatment.
Material and methods: The study included 22 children aged 11.5-17 years (mean 14.5) hospitalized with newly diagnosed multiple sclerosis, hospitalized in 2016-2018 in the University Children´s Hospital in Krakow. According to the type of the first clinical symptoms, children were divided into three groups. Group I consisted of 11 children with visual impairment, group II of 7 children with sensory and motor abnormalities, while in group III there were 4 children with impaired vision and sensation. In all children, in the initial diagnostic process, exogenous evoked potentials (VEP,BAEP,SEP) and endogenous evoked P300 potential were made.
Results: In the VEP study, elongated P100 latencies in all patients, P100 amplitude was normal in 20 children and in 2 was decrease. In the BAEP examination, normal latencies and interlatencies of waves I-III, III-V, I-V in all children was obtained. At the median nerve, slightly elongated latency N9 was obtained in group I-9.62+/-0.81ms, in group II-9.76+/0.75ms, in group III-9.41+/-0.81ms, P14 in group I-14.46+/-1.25ms, N18 in group III 18.43+/-1.3ms, N20 was normal in all groups. In the study of endogenous potentials, a slight elongation of the P300 latency in group I-332.55+/-26.70ms and, in group II-327.43+/-17.70ms, in the group III- 329.75+/-21.86ms, and a reduced amplitude in group II-2.37+/-4.82uV, compared to the control group.
Conclusions:
1. VEP is a sensitive neurophysiological method in the objective assessment of retrobulbar optic neuritis, and in clinically silent optic pathways involvement
2. The integrity of the auditory pathway in children with MS at the early onset of the disease remains unaffected
3. The prolongation of the latency of waves in the SEP study corresponds to the clinical symptoms
4. The prolongation of P300 latency may indicate a cognitive impairment in children with newly diagnosed MS
Disclosure: Witek : I have nothing to disclose
Kroczka: I have nothing to disclose
Stolarska: I have nothing to disclose