Contributions
Abstract: EP1321
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Paediatric MS
Objective: The aim of this study was to evaluate the anterior optic pathway in children with the diagnosis of acute disseminated encephalomyelitis (ADEM) with or without clinical Optic neuritis measuring the peripapillar retinal nerve fibre layer (RNFL) thickness by optical coherence tomography (OCT)
Methods: A cross-sectional study of 8 patients (2/8 with positive titles of anti-MOG IgG) diagnosed with monophasic ADEM between 2010-2017 in a tertiary pediatric hospital. Data about onset symptoms, subjective complaints and school performance after the episode were collected. The presence of dyschromatopsia was evaluated with the Ishihara test, the manual ability through the Nine Peg Hole test (NPHT) and the presence of executive alterations with parts A and B of the standardized Trail Making test(TMT). Brain MRI of the episode was evaluated using the 16-parameter score system suggested by Verhey et al. The average and segment thickness of the RNFL was measured by OCT (Heidelberg Spectralis) in both eyes.
Results: Median age at onset was 44 (range: 4-96) months and the evaluation was made at 8 (range: 4-10) years. Symptoms at onset were fever and encephalopathy (8/8), brainstem focality (6/8) cerebellar focality (5/8) and epileptic seizures (2/8). Learning difficulties during the follow-up, although one of them had psychomotor retardation prior to the ADEM episode. The Ishihara test was normal, the NPHT in 7/8. Basal MRI showed involvement of gray matter and white matter (8/8 patients), thalamic (6/8) and optic nerves (1/8, anti-MOG +) involment. Only 2 patients have a pRNFL thickning and they were anti-MOG +; presenting a global alteration in the case with MRI involvement of the optic nerves and a crossed alteration of the nasal and temporal segments in the other case.
Conclusions: OCT may be a valuable tool for the evaluation and monitoring of optic pathway dysfunction in children with demyelinating diseases. Patients with positive anti-MOG may be more susceptible of sequelae which can be detected by OCT.
Disclosure: Nothing to disclose.
Abstract: EP1321
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Paediatric MS
Objective: The aim of this study was to evaluate the anterior optic pathway in children with the diagnosis of acute disseminated encephalomyelitis (ADEM) with or without clinical Optic neuritis measuring the peripapillar retinal nerve fibre layer (RNFL) thickness by optical coherence tomography (OCT)
Methods: A cross-sectional study of 8 patients (2/8 with positive titles of anti-MOG IgG) diagnosed with monophasic ADEM between 2010-2017 in a tertiary pediatric hospital. Data about onset symptoms, subjective complaints and school performance after the episode were collected. The presence of dyschromatopsia was evaluated with the Ishihara test, the manual ability through the Nine Peg Hole test (NPHT) and the presence of executive alterations with parts A and B of the standardized Trail Making test(TMT). Brain MRI of the episode was evaluated using the 16-parameter score system suggested by Verhey et al. The average and segment thickness of the RNFL was measured by OCT (Heidelberg Spectralis) in both eyes.
Results: Median age at onset was 44 (range: 4-96) months and the evaluation was made at 8 (range: 4-10) years. Symptoms at onset were fever and encephalopathy (8/8), brainstem focality (6/8) cerebellar focality (5/8) and epileptic seizures (2/8). Learning difficulties during the follow-up, although one of them had psychomotor retardation prior to the ADEM episode. The Ishihara test was normal, the NPHT in 7/8. Basal MRI showed involvement of gray matter and white matter (8/8 patients), thalamic (6/8) and optic nerves (1/8, anti-MOG +) involment. Only 2 patients have a pRNFL thickning and they were anti-MOG +; presenting a global alteration in the case with MRI involvement of the optic nerves and a crossed alteration of the nasal and temporal segments in the other case.
Conclusions: OCT may be a valuable tool for the evaluation and monitoring of optic pathway dysfunction in children with demyelinating diseases. Patients with positive anti-MOG may be more susceptible of sequelae which can be detected by OCT.
Disclosure: Nothing to disclose.