Contributions
Abstract: EP1312
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Objective: Neuromyelitis optica spectram disorders (NMOSD) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system. The aim of this study was to elucidate dynamics of cognition in a Japanese cohort of NMOSD and MS during long-term courses.
Methods: We performed a longitudinal study for 16 patients with MS and 12 patients with NMOSD. All patients were investigated for clinical features and were performed using the Brief Repeatable Battery of Neuropsychological Test (BRB-N) at baseline and at least 3 year-follow-up.
Results: The mean follow-up periods for assessments were 6.8 years and 5.6 years in NMOSD patients (male/female = 1/11) and MS patients (male/female = 6/10), respectively. Three patients (19%) with MS had progressive courses, but other patients with NMOSD and MS did not. The mean ages at basement of assessments were 49.5 (SD 10.8) years and 39.3 (SD 8.5) years, and frequencies of taking treatments were 75% (steroid treatments) and 69% (disease-modifying treatments including interferon b) in NMOSD and MS patients, respectively. During the follow-up study, the mean annualized relapse rates were 0.2 (SD 0.2) and 0.1 (SD 0.1), the mean annualized changes of EDSS change were 0.1 (SD 0.3) and 0.0 (SD 0.3) in NMOSD and MS patients, respectively. During the follow-up study, the BRB-N index of MS patients had significantly deteriorated compared to NMOSD patients (P < 0.001). Among the items of the BRB-N, symbol digit modality test (P = 0.012), delayed selective reminding test (P = 0.013), spatial recall test (SPART)(P = 0.049) and delayed SPART (P = 0.038) had significantly deteriorated in MS patients, compared to NMOSD patients.
Conclusion: BRB-N is a useful assessment in evaluating cognitive function of NMOSD and MS during long-term courses. These data suggest that dynamics of cognitive impairment and neurodegenerative processes were distinct differences between NMOSD and MS during at least 3 year-follow-up.
Disclosure: E. Saji has received research support from a JSPS KAKENHI Grant. I. Kawachi has received funding for research, travel/speaker honoraria or serving on scientific advisory boards from Novartis, Biogen, Bayer, Mitsubishi Tanabe, Astellas and JB, and research support from a JSPS KAKENHI Grant. T. Wakasugi, F. Yanagimura, M. Hokari, K. Yanagawa, Y. and O. Onodera have nothing to disclose.
Abstract: EP1312
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Objective: Neuromyelitis optica spectram disorders (NMOSD) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system. The aim of this study was to elucidate dynamics of cognition in a Japanese cohort of NMOSD and MS during long-term courses.
Methods: We performed a longitudinal study for 16 patients with MS and 12 patients with NMOSD. All patients were investigated for clinical features and were performed using the Brief Repeatable Battery of Neuropsychological Test (BRB-N) at baseline and at least 3 year-follow-up.
Results: The mean follow-up periods for assessments were 6.8 years and 5.6 years in NMOSD patients (male/female = 1/11) and MS patients (male/female = 6/10), respectively. Three patients (19%) with MS had progressive courses, but other patients with NMOSD and MS did not. The mean ages at basement of assessments were 49.5 (SD 10.8) years and 39.3 (SD 8.5) years, and frequencies of taking treatments were 75% (steroid treatments) and 69% (disease-modifying treatments including interferon b) in NMOSD and MS patients, respectively. During the follow-up study, the mean annualized relapse rates were 0.2 (SD 0.2) and 0.1 (SD 0.1), the mean annualized changes of EDSS change were 0.1 (SD 0.3) and 0.0 (SD 0.3) in NMOSD and MS patients, respectively. During the follow-up study, the BRB-N index of MS patients had significantly deteriorated compared to NMOSD patients (P < 0.001). Among the items of the BRB-N, symbol digit modality test (P = 0.012), delayed selective reminding test (P = 0.013), spatial recall test (SPART)(P = 0.049) and delayed SPART (P = 0.038) had significantly deteriorated in MS patients, compared to NMOSD patients.
Conclusion: BRB-N is a useful assessment in evaluating cognitive function of NMOSD and MS during long-term courses. These data suggest that dynamics of cognitive impairment and neurodegenerative processes were distinct differences between NMOSD and MS during at least 3 year-follow-up.
Disclosure: E. Saji has received research support from a JSPS KAKENHI Grant. I. Kawachi has received funding for research, travel/speaker honoraria or serving on scientific advisory boards from Novartis, Biogen, Bayer, Mitsubishi Tanabe, Astellas and JB, and research support from a JSPS KAKENHI Grant. T. Wakasugi, F. Yanagimura, M. Hokari, K. Yanagawa, Y. and O. Onodera have nothing to disclose.