Contributions
Abstract: EP1311
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory disorder of the central nervous system that predominantly affects the optic nerve and spinal cord. So far in Ecuador, there are no reports regarding this disease.
Objective: To report demographic, clinical, and radiological data of NMOSD patients in third level hospitals of Ecuador.
Methods: Using the 2015 revised NMOSD criteria, we retrospectively reviewed the medical records of patients who were attended at Hospital Carlos Andrade Marín, Hospital General de las Fuerzas Armadas and Hospital Eugenio Espejo in Quito, Hospital Teodoro Maldonado Carbo in Guayaquil and Hospital José Carrasco Arteaga in Cuenca, all of which are references centres for NMO in Ecuador, from January 2015 to Abril 2018.
Results: We recruited 59 patients, 47 of whom were female (80%). The ratio female to male was 3.9/1. The median age was 43 years SD +/- 15.21 (range 15-73). Mean age at onset of the 1st symptom was 37.2 years (range 11-69). At presentation of the first symptom, 10 patients (16.9%) had transverse myelitis (TM), 22 (37%) had optic neuritis (ON), 24 (40.6%) had simultaneous TM and ON and 9 (15%) had hiccups and/or vomiting. The clinically established manifestations were, unilateral ON 32%, bilateral ON 49.15%, motor symptoms (93.2%), sensory symptoms (79.6%) and autonomic symptoms 42.37%. Longitudinally extensive transverse myelitis (LEMT), which was established by magnetic resonance imaging was present in 88% of patients. Cervical, cervical/thoracic and thoracic spinal cord damage was present in 37.2%, 35.59% and 15.25% respectively. Brain MRI abnormalities were present in 5 patients (8.4%). Out of the 51 patients tested, 40 (78%) were AQP4-IgG (+). The Median Expanded Disability Status Score (EDSS) was 4.9.
Conclusions: This is the first cohort of NMOSD described in third level hospitals in Ecuador, 80% of patients were female. At the onset of the disease, simultaneous TM and ON were present in 78% of patients. In MRI scans, LEMT was present in 88% of patients and brain abnormalities were infrequent. Positive antibodies for AQP4 were present in 78% of patients. The behaviour of this disease in Ecuador is different if compared with studies of cohorts from other countries.
Disclosure: Edgar Patricio Correa Díaz: nothing to disclose
Torres Germaine: nothing to disclose
Guillen Fernando: nothing to disclose
Acuña Gabriela: nothing to disclose
Arroyo Hyland: nothing to disclose
Narvaez Beatriz: nothing to disclose
Saltos Malta: nothing to disclose
Santos Denny: nothing to disclose
Caiza Francisco: nothing to disclose
Santacruz María José: nothing to disclose
Gualotuña Edwin: nothing to disclose
López Manuel: nothing to disclose
Llerena Andrea: nothing to disclose
Nuñez Verónica: nothing to disclose
Reyes María Augusta: nothing to disclose
Merchan Daniel: nothing to disclose
Jara María: nothing to disclose
Abstract: EP1311
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory disorder of the central nervous system that predominantly affects the optic nerve and spinal cord. So far in Ecuador, there are no reports regarding this disease.
Objective: To report demographic, clinical, and radiological data of NMOSD patients in third level hospitals of Ecuador.
Methods: Using the 2015 revised NMOSD criteria, we retrospectively reviewed the medical records of patients who were attended at Hospital Carlos Andrade Marín, Hospital General de las Fuerzas Armadas and Hospital Eugenio Espejo in Quito, Hospital Teodoro Maldonado Carbo in Guayaquil and Hospital José Carrasco Arteaga in Cuenca, all of which are references centres for NMO in Ecuador, from January 2015 to Abril 2018.
Results: We recruited 59 patients, 47 of whom were female (80%). The ratio female to male was 3.9/1. The median age was 43 years SD +/- 15.21 (range 15-73). Mean age at onset of the 1st symptom was 37.2 years (range 11-69). At presentation of the first symptom, 10 patients (16.9%) had transverse myelitis (TM), 22 (37%) had optic neuritis (ON), 24 (40.6%) had simultaneous TM and ON and 9 (15%) had hiccups and/or vomiting. The clinically established manifestations were, unilateral ON 32%, bilateral ON 49.15%, motor symptoms (93.2%), sensory symptoms (79.6%) and autonomic symptoms 42.37%. Longitudinally extensive transverse myelitis (LEMT), which was established by magnetic resonance imaging was present in 88% of patients. Cervical, cervical/thoracic and thoracic spinal cord damage was present in 37.2%, 35.59% and 15.25% respectively. Brain MRI abnormalities were present in 5 patients (8.4%). Out of the 51 patients tested, 40 (78%) were AQP4-IgG (+). The Median Expanded Disability Status Score (EDSS) was 4.9.
Conclusions: This is the first cohort of NMOSD described in third level hospitals in Ecuador, 80% of patients were female. At the onset of the disease, simultaneous TM and ON were present in 78% of patients. In MRI scans, LEMT was present in 88% of patients and brain abnormalities were infrequent. Positive antibodies for AQP4 were present in 78% of patients. The behaviour of this disease in Ecuador is different if compared with studies of cohorts from other countries.
Disclosure: Edgar Patricio Correa Díaz: nothing to disclose
Torres Germaine: nothing to disclose
Guillen Fernando: nothing to disclose
Acuña Gabriela: nothing to disclose
Arroyo Hyland: nothing to disclose
Narvaez Beatriz: nothing to disclose
Saltos Malta: nothing to disclose
Santos Denny: nothing to disclose
Caiza Francisco: nothing to disclose
Santacruz María José: nothing to disclose
Gualotuña Edwin: nothing to disclose
López Manuel: nothing to disclose
Llerena Andrea: nothing to disclose
Nuñez Verónica: nothing to disclose
Reyes María Augusta: nothing to disclose
Merchan Daniel: nothing to disclose
Jara María: nothing to disclose