Contributions
Abstract: EP1303
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Neurosarcoidosis (NS) is a rare and polymorphic entity, often inaugural and isolated. To date, diagnostic assessment is still a matter of debate.
We sought to describe a cohort of patients diagnosed with NS and to establish the relevance of diagnostic investigations.
A retrospective study of all patients diagnosed with NS was conducted in Rouen University Hospital between 1993 and 2018. We included patients diagnosed with definite, probable and possible NS, as described by Zajiceck et al., and collected clinical, biological and imaging data. We distinguished patients with inaugural NS from those already diagnosed with systemic sarcoidosis.
A total of 30 patients were included, 18 (61%) of whom with inaugural NS. Sex ratio male/female was 0.87. The mean age of onset was 43.26 years. NS was considered as definite in two patients (7%), probable in 20 (66%) and possible in eight (27%). The median time to diagnostic was 4.2 months. In cases of already known sarcoidosis, neurological symptoms mainly occurred within 6 months after the onset of sarcoidosis (0.83). Pulmonary manifestations were associated in nine patients (30%). Headache (56%), cranial neuropathies (56%), such as facial nerve palsy, and seizure (30%) were the most common signs. Only three patients (10%) presented longitudinal extensive traverse myelitis and four patients (13%) peripheral nervous impairment. Biological tests showed: lymphopenia (86%), increased ACE levels (47%), stigmata of autoimmunity (37%). CSF analysis revealed : lymphocytic pleocytosis (47%), high protein content (82%). Diffuse T2 white matter hyperintensities (85%) and focal meningeal enhancement (55%) were the most common brain MRI finding. Sensitivity of CSF analysis and MRI was about 84%, whereas, in other tests, about 41%. No difference was found in terms of demographic features, biological tests and imaging between the two groups. Patients with inaugural NS had significantly more parenchymal symptoms than others (44% vs 8%, p= 0.049).
No statistically significant difference was seen between the two groups except for parenchymal symptoms more frequent in inaugural NS patients than others. Sensitivity of CSF analysis and MRI was 84% showing the interest of these two investigations in suspected cases of NS.
Disclosure: Nothing to disclose
Abstract: EP1303
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Neurosarcoidosis (NS) is a rare and polymorphic entity, often inaugural and isolated. To date, diagnostic assessment is still a matter of debate.
We sought to describe a cohort of patients diagnosed with NS and to establish the relevance of diagnostic investigations.
A retrospective study of all patients diagnosed with NS was conducted in Rouen University Hospital between 1993 and 2018. We included patients diagnosed with definite, probable and possible NS, as described by Zajiceck et al., and collected clinical, biological and imaging data. We distinguished patients with inaugural NS from those already diagnosed with systemic sarcoidosis.
A total of 30 patients were included, 18 (61%) of whom with inaugural NS. Sex ratio male/female was 0.87. The mean age of onset was 43.26 years. NS was considered as definite in two patients (7%), probable in 20 (66%) and possible in eight (27%). The median time to diagnostic was 4.2 months. In cases of already known sarcoidosis, neurological symptoms mainly occurred within 6 months after the onset of sarcoidosis (0.83). Pulmonary manifestations were associated in nine patients (30%). Headache (56%), cranial neuropathies (56%), such as facial nerve palsy, and seizure (30%) were the most common signs. Only three patients (10%) presented longitudinal extensive traverse myelitis and four patients (13%) peripheral nervous impairment. Biological tests showed: lymphopenia (86%), increased ACE levels (47%), stigmata of autoimmunity (37%). CSF analysis revealed : lymphocytic pleocytosis (47%), high protein content (82%). Diffuse T2 white matter hyperintensities (85%) and focal meningeal enhancement (55%) were the most common brain MRI finding. Sensitivity of CSF analysis and MRI was about 84%, whereas, in other tests, about 41%. No difference was found in terms of demographic features, biological tests and imaging between the two groups. Patients with inaugural NS had significantly more parenchymal symptoms than others (44% vs 8%, p= 0.049).
No statistically significant difference was seen between the two groups except for parenchymal symptoms more frequent in inaugural NS patients than others. Sensitivity of CSF analysis and MRI was 84% showing the interest of these two investigations in suspected cases of NS.
Disclosure: Nothing to disclose