Abstract: EP1298
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: An overlapping of symptoms among multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) may be found at disease onset. Recently, magnetic resonance imaging (MRI) criteria (Matthews's criteria, MC) were described to differentiate MS from NMOSD in clinical practice. However, these criteria were not evaluated in non-Caucasian population. The aim was to evaluate these criteria in Latin American population.
Methods: medical records and brain MRIs were assessed by a blind evaluator and scored on the MC (lesions adjacent to the body of the lateral ventricle, lesions in inferior temporal lobe, S-shaped/curved U-fibre lesions and Dawson's fingers) in a Latin American cohort (Argentina, Brazil and Venezuela) of patients with MS and NMOSD (previously diagnosed by current validated diagnosis criteria and used as gold standard). MC sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined.
Results: We included 282 patients (MS = 188 and NMOSD = 94, ratio 2:1). Patients from Argentina (MS = 92, NMOSD = 38), Brazil (MS = 55, NMOSD = 27) and Venezuela (MS = 29, NMOSD = 41) were evaluated at disease onset. The MC applied to the entire cohort at disease onset showed a 97.8% sensitivity, 82.9% specificity, 92.0% PPV, and 95.1% NPV in differentiate MS from NMOSD. The sub-analysis applied only to non-Caucasian populations (mestizos, natives and zambos, MS = 89 and NMOSD = 47) showed a 100% sensitivity, 80.8% specificity, 90.8% PPV, and 100% NPV.
Conclusion: These findings suggest that the MC distinguished MS from NMOSD at disease onset in a Latin American cohort.
Disclosure: None of the authors has any potential financial conflict of interest related to this poster
Abstract: EP1298
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: An overlapping of symptoms among multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) may be found at disease onset. Recently, magnetic resonance imaging (MRI) criteria (Matthews's criteria, MC) were described to differentiate MS from NMOSD in clinical practice. However, these criteria were not evaluated in non-Caucasian population. The aim was to evaluate these criteria in Latin American population.
Methods: medical records and brain MRIs were assessed by a blind evaluator and scored on the MC (lesions adjacent to the body of the lateral ventricle, lesions in inferior temporal lobe, S-shaped/curved U-fibre lesions and Dawson's fingers) in a Latin American cohort (Argentina, Brazil and Venezuela) of patients with MS and NMOSD (previously diagnosed by current validated diagnosis criteria and used as gold standard). MC sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined.
Results: We included 282 patients (MS = 188 and NMOSD = 94, ratio 2:1). Patients from Argentina (MS = 92, NMOSD = 38), Brazil (MS = 55, NMOSD = 27) and Venezuela (MS = 29, NMOSD = 41) were evaluated at disease onset. The MC applied to the entire cohort at disease onset showed a 97.8% sensitivity, 82.9% specificity, 92.0% PPV, and 95.1% NPV in differentiate MS from NMOSD. The sub-analysis applied only to non-Caucasian populations (mestizos, natives and zambos, MS = 89 and NMOSD = 47) showed a 100% sensitivity, 80.8% specificity, 90.8% PPV, and 100% NPV.
Conclusion: These findings suggest that the MC distinguished MS from NMOSD at disease onset in a Latin American cohort.
Disclosure: None of the authors has any potential financial conflict of interest related to this poster