Contributions
Abstract: EP1293
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Introduction: Clinically isolated syndrome (CIS) is a first demyelinating event targeting the central nervous system. It can latter fulfil the criteria for Multiple Sclerosis (MS) but in some patients it is an isolated episode, without new clinical events or paraclinical evidence of disease.
Objectives/Aims: To analyse our population of CIS patients and the role of OCB in the 2017 revision of the McDonald criteria
Methods: We selected those patients who had ever had a diagnosis of CIS, observed in our MS clinic (N= 69), according to the 2010 McDonald criteria. Clinical and laboratorial features were analysed to compare those who converted to MS and the non-converters.
Results: From the total cohort, 71% converted to MS, at a median follow-up of 2 years (0-11 years). Those who converted to MS were tendencially younger (28 vs 33 years; p=0,066) and had an elevated level of cerebrospinal fluid (CSF) proteins (0,51 vs 0,30 g/L; p=0,072). Our analysis found no association between the presenting symptom, altered visual potentials with conversion to MS. OCB were present in 64,1% of patients who were diagnosed with MS, but also in 68,4% of those who remained CIS (p=0.745). Stratifying the results by treatment, there was also no statistical significant association between the presence of oligoclonal bands and conversion to MS.
Conclusion: The present study showed that OCB is prevalent in patients with CIS, even in those who, until now, do not fulfil the 2010 diagnostic criteria for MS. This raises questions about the early assumption of MS diagnosis, resulting in chronic treatment and a possibly lifelong stigma in patients who could never develop new lesions or have a second attack.
Disclosure: Mafalda Seabra: nothing to disclose
Mónica Teixeira: nothing to disclose
Lúcia Carvalho: nothing to disclose
Lucinda Sequeira: nothing to disclose
Pedro Abreu: nothing to disclose
Teresa Mendonça: nothing to disclose
Jorge Reis: nothing to disclose
Maria José Sá: nothing to disclose
Joana Guimarães: nothing to disclose
Abstract: EP1293
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Introduction: Clinically isolated syndrome (CIS) is a first demyelinating event targeting the central nervous system. It can latter fulfil the criteria for Multiple Sclerosis (MS) but in some patients it is an isolated episode, without new clinical events or paraclinical evidence of disease.
Objectives/Aims: To analyse our population of CIS patients and the role of OCB in the 2017 revision of the McDonald criteria
Methods: We selected those patients who had ever had a diagnosis of CIS, observed in our MS clinic (N= 69), according to the 2010 McDonald criteria. Clinical and laboratorial features were analysed to compare those who converted to MS and the non-converters.
Results: From the total cohort, 71% converted to MS, at a median follow-up of 2 years (0-11 years). Those who converted to MS were tendencially younger (28 vs 33 years; p=0,066) and had an elevated level of cerebrospinal fluid (CSF) proteins (0,51 vs 0,30 g/L; p=0,072). Our analysis found no association between the presenting symptom, altered visual potentials with conversion to MS. OCB were present in 64,1% of patients who were diagnosed with MS, but also in 68,4% of those who remained CIS (p=0.745). Stratifying the results by treatment, there was also no statistical significant association between the presence of oligoclonal bands and conversion to MS.
Conclusion: The present study showed that OCB is prevalent in patients with CIS, even in those who, until now, do not fulfil the 2010 diagnostic criteria for MS. This raises questions about the early assumption of MS diagnosis, resulting in chronic treatment and a possibly lifelong stigma in patients who could never develop new lesions or have a second attack.
Disclosure: Mafalda Seabra: nothing to disclose
Mónica Teixeira: nothing to disclose
Lúcia Carvalho: nothing to disclose
Lucinda Sequeira: nothing to disclose
Pedro Abreu: nothing to disclose
Teresa Mendonça: nothing to disclose
Jorge Reis: nothing to disclose
Maria José Sá: nothing to disclose
Joana Guimarães: nothing to disclose