Contributions
Abstract: P1167
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Recent study (Toro et al, 2018) highlighted the presence of impulsivity traits in relation with depression in Multiple Sclerosis (MS). Impulsivity is known to be multifactorial. Dickman scale (FIDI) allows distinguishing functional impulsivity (FI), which is the ability to react fast and properly when it is necessary and dysfunctional impulsivity (DI) which is the tendency to miss forethought before acting. Furthermore the influence of MS type on impulsivity has not been taken in consideration until now.
Objective: Investigate functional and dysfunctional impulsivity in relapsing remitting (RR) and progressive (P) forms of MS.
Methods: 57 MS patients were prospectively recruited at the MS Center of Nice. They filled FIDI scale for impulsivity evaluation, Fast BDI to measure depression, EMIF scale to investigate fatigue and ran the CSCT to measure processing speed of information.
Results: Demographic characteristics: 32 RRMS, 24 women, 8 men, mean age: 39.6 years (SD: 9.2, 23-60), median EDSS score: 2 (0-7), and mean disease duration in months (122, ET: 76, 12-300). 25 PMS (16 Secondary Progressive, and 9 Primary Progressive), 15 women, 10 men, mean age: 39.6 years (SD: 9.2, 23-60), median EDSS score: 2 (0-7), and mean disease duration in months (122, SD: 76, 12-300). MS patients did not show pathological mean zscore in FI (RRMS; -0.73, SD: 1.2, -2.7-1.5; PMS: FI: -0.52, SD: 1.1, -2.7-1.46), neither in DI (RRMS: -0.25, SD: 1.0, -2.6-1.1; PMS: 0.37, SD: 0.7, -1.8-1.1). Nevertheless the RRMS patients showed significantly more DI than the PMS patients (ANOVA: F=6.59, p=0.01). There was no significant difference between groups on FI (ANOVA: F=0.44, p=0.5). Depression did not have a significant effect on DI (F=0.3, p=0.6). When taking in account depression, fatigue, processing speed of information, and disease duration through a multiple linear regression, only the fatigue physical (p= 0.001) and cognitive components (p=0.003) had a significant impact on DI.
Conclusions and perspectives: Our study did not show pathological impulsivity in MS. However, dysfunctional impulsivity is more severe in RRMS than in PMS patients. The only study to our knowledge showing impulsivity in MS was mainly composed of RRMS and impulsivity appeared only in depressed patients. Depression did not impact dysfunctional impulsivity but physical and cognitive fatigue did. Further research will aim to investigate the relation between MRI data and dysfunctional impulsivity in MS.
Disclosure: Joly H., Capet N., Suply C., Bresch S., Cohen M., and Lebrun C.: nothing to disclose.
Abstract: P1167
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Recent study (Toro et al, 2018) highlighted the presence of impulsivity traits in relation with depression in Multiple Sclerosis (MS). Impulsivity is known to be multifactorial. Dickman scale (FIDI) allows distinguishing functional impulsivity (FI), which is the ability to react fast and properly when it is necessary and dysfunctional impulsivity (DI) which is the tendency to miss forethought before acting. Furthermore the influence of MS type on impulsivity has not been taken in consideration until now.
Objective: Investigate functional and dysfunctional impulsivity in relapsing remitting (RR) and progressive (P) forms of MS.
Methods: 57 MS patients were prospectively recruited at the MS Center of Nice. They filled FIDI scale for impulsivity evaluation, Fast BDI to measure depression, EMIF scale to investigate fatigue and ran the CSCT to measure processing speed of information.
Results: Demographic characteristics: 32 RRMS, 24 women, 8 men, mean age: 39.6 years (SD: 9.2, 23-60), median EDSS score: 2 (0-7), and mean disease duration in months (122, ET: 76, 12-300). 25 PMS (16 Secondary Progressive, and 9 Primary Progressive), 15 women, 10 men, mean age: 39.6 years (SD: 9.2, 23-60), median EDSS score: 2 (0-7), and mean disease duration in months (122, SD: 76, 12-300). MS patients did not show pathological mean zscore in FI (RRMS; -0.73, SD: 1.2, -2.7-1.5; PMS: FI: -0.52, SD: 1.1, -2.7-1.46), neither in DI (RRMS: -0.25, SD: 1.0, -2.6-1.1; PMS: 0.37, SD: 0.7, -1.8-1.1). Nevertheless the RRMS patients showed significantly more DI than the PMS patients (ANOVA: F=6.59, p=0.01). There was no significant difference between groups on FI (ANOVA: F=0.44, p=0.5). Depression did not have a significant effect on DI (F=0.3, p=0.6). When taking in account depression, fatigue, processing speed of information, and disease duration through a multiple linear regression, only the fatigue physical (p= 0.001) and cognitive components (p=0.003) had a significant impact on DI.
Conclusions and perspectives: Our study did not show pathological impulsivity in MS. However, dysfunctional impulsivity is more severe in RRMS than in PMS patients. The only study to our knowledge showing impulsivity in MS was mainly composed of RRMS and impulsivity appeared only in depressed patients. Depression did not impact dysfunctional impulsivity but physical and cognitive fatigue did. Further research will aim to investigate the relation between MRI data and dysfunctional impulsivity in MS.
Disclosure: Joly H., Capet N., Suply C., Bresch S., Cohen M., and Lebrun C.: nothing to disclose.