Contributions
Abstract: P1042
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Introduction: A clinically isolated syndrome (CIS) is defined as a clinical demyelinating event that is often the initial attack of relapsing remitting Multiple Sclerosis (RRMS) and optic neuritis (ON) can beone of the presenting symptoms.
Methods: We included 75 patients who came to our department for their first demyelinating episode suggestive of multiple sclerosis between January 2010 and December 2016. All patients underwent complete ophthalmological examination (OE) and VEPs.
Results: The mean age at onset was 30 years (12-61 years) with a female predominance. At ophthalmological examination, only 69,7 % of cases presented a unilateral decreased visual acuity. Among these patients, VEPs showed a retro-bulbar ON (NORB) that was unilateral in 14 cases (26,4%) and bilateral in 34 cases (64,2%). VEPs was normal in 4 cases (7,5%) and demonstrated axonal loss in one case (1,9%). In patients with normal OE , VEPs showed unilateral NORB in 2 patients (9,1%) and bilateral NORB in 4 cases (18,2%).
Discussion: ON occur as a first demyelinating event of RRMS in 20% of cases. Its diagnosis is clinical and electrophysiological using VEPs. Although CIS have until today a clinical definition without any paraclinical support, it appear through our results that CIS manifesting as only ON needs further electrophysiological support. Indeed, in our study, 27,3% of patients with normal ophthalmological examination showed altered VEPs and 7,5% of patients with decreased visual acuity yield normal VEPs. In the other hand, almost of patients with unilateral ON carry contralateral optic nerve insult on VEPs.
Conclusion: VEPs play a major role to make ON diagnosis as well as studying its characteristic and thus they should be considered when someone presents with a first demyelinating events manifesting as ON.
Disclosure: No conflicts of interest
Nothing to disclose
Abstract: P1042
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Introduction: A clinically isolated syndrome (CIS) is defined as a clinical demyelinating event that is often the initial attack of relapsing remitting Multiple Sclerosis (RRMS) and optic neuritis (ON) can beone of the presenting symptoms.
Methods: We included 75 patients who came to our department for their first demyelinating episode suggestive of multiple sclerosis between January 2010 and December 2016. All patients underwent complete ophthalmological examination (OE) and VEPs.
Results: The mean age at onset was 30 years (12-61 years) with a female predominance. At ophthalmological examination, only 69,7 % of cases presented a unilateral decreased visual acuity. Among these patients, VEPs showed a retro-bulbar ON (NORB) that was unilateral in 14 cases (26,4%) and bilateral in 34 cases (64,2%). VEPs was normal in 4 cases (7,5%) and demonstrated axonal loss in one case (1,9%). In patients with normal OE , VEPs showed unilateral NORB in 2 patients (9,1%) and bilateral NORB in 4 cases (18,2%).
Discussion: ON occur as a first demyelinating event of RRMS in 20% of cases. Its diagnosis is clinical and electrophysiological using VEPs. Although CIS have until today a clinical definition without any paraclinical support, it appear through our results that CIS manifesting as only ON needs further electrophysiological support. Indeed, in our study, 27,3% of patients with normal ophthalmological examination showed altered VEPs and 7,5% of patients with decreased visual acuity yield normal VEPs. In the other hand, almost of patients with unilateral ON carry contralateral optic nerve insult on VEPs.
Conclusion: VEPs play a major role to make ON diagnosis as well as studying its characteristic and thus they should be considered when someone presents with a first demyelinating events manifesting as ON.
Disclosure: No conflicts of interest
Nothing to disclose