Contributions
Abstract: P1041
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Optic neuritis is associated with retrograde degeneration of optic nerve axons detected and quantified by spectral domain optical coherence tomography and reflected typically by thinning of the inner retinal layers (the peripapillary retinal nerve fiber layer and, the combined ganglion cell and inner plexiform layers). Our aim was to report in 8 patients with acute optic neuritis, the presence of acute macular neuro retinopathy type 2, a rare but increasingly identified disorder of the outer retinal layers, with classically reddish-brown and wedge-shaped retinal lesions, the apices of which tend to be directed toward the fovea in a petalloid configuration. On spectral domain optical coherence, at the site of the lesions seen on infrared scanning laser ophthalmoscopy, acute macular neuro retinopathy disclosed a hyperreflective lesion at the level of outer plexiform layer (OPL)-outer nuclear layer (ONL). As a reminder, the ONL contains the rod and cone cell bodies, and the OPL the synapses between horizontal cells or bipolar cells from the inner nuclear layer and photoreceptor terminal axons from the ONL. Among the 8 patients (6 females; mean age = 35.9 years; range = 23 to 56 years), 4 were positive for myelin oligodendrocyte glycoprotein antibodies, 3 had relapsing remitting multiple sclerosis and one had clinical isolated syndrome. Possible vascular pathophysiological mechanisms including ischemia in the territory of retinal capillaries (likely of the deep capillary plexus that vascularize the outer retinal layers) are discussed.
In conclusion, we confirm the possible involvement of the outer retinal layers after acute optic neuritis. The association of acute macular neuro retinopathy with optic neuritis has never been described to our knowledge.
Disclosure: Deschamps: nothing to disclose
Vasseur : nothing to disclose
Shor: nothing to disclose
Vignal: nothing to disclose
Gout: nothing to disclose
Mauget-Faÿsse :nothing to disclose
Abstract: P1041
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Neuro-ophthalmology
Optic neuritis is associated with retrograde degeneration of optic nerve axons detected and quantified by spectral domain optical coherence tomography and reflected typically by thinning of the inner retinal layers (the peripapillary retinal nerve fiber layer and, the combined ganglion cell and inner plexiform layers). Our aim was to report in 8 patients with acute optic neuritis, the presence of acute macular neuro retinopathy type 2, a rare but increasingly identified disorder of the outer retinal layers, with classically reddish-brown and wedge-shaped retinal lesions, the apices of which tend to be directed toward the fovea in a petalloid configuration. On spectral domain optical coherence, at the site of the lesions seen on infrared scanning laser ophthalmoscopy, acute macular neuro retinopathy disclosed a hyperreflective lesion at the level of outer plexiform layer (OPL)-outer nuclear layer (ONL). As a reminder, the ONL contains the rod and cone cell bodies, and the OPL the synapses between horizontal cells or bipolar cells from the inner nuclear layer and photoreceptor terminal axons from the ONL. Among the 8 patients (6 females; mean age = 35.9 years; range = 23 to 56 years), 4 were positive for myelin oligodendrocyte glycoprotein antibodies, 3 had relapsing remitting multiple sclerosis and one had clinical isolated syndrome. Possible vascular pathophysiological mechanisms including ischemia in the territory of retinal capillaries (likely of the deep capillary plexus that vascularize the outer retinal layers) are discussed.
In conclusion, we confirm the possible involvement of the outer retinal layers after acute optic neuritis. The association of acute macular neuro retinopathy with optic neuritis has never been described to our knowledge.
Disclosure: Deschamps: nothing to disclose
Vasseur : nothing to disclose
Shor: nothing to disclose
Vignal: nothing to disclose
Gout: nothing to disclose
Mauget-Faÿsse :nothing to disclose