Contributions
Abstract: P1036
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Economic burden
Introduction: The economic situation of individuals diagnosed with multiple sclerosis (MS) is relatively unknown, with income suggested to vary with sociodemographic characteristics.
Aim: To identify the diversity of disposable income (DI) trajectories within working-aged people with incident MS, and investigate the associations of sociodemographic characteristics with identified trajectories.
Methods: A population-based cohort study of all 1528 individuals aged 25-59 who had their first MS diagnosis registered in 2008-2009, using data linked from three nationwide Swedish registers. We analysed mean annual DI (benefits and earnings after excluding taxes), earnings, and work disability (net days with reimbursed sickness absence and disability pension benefits) from seven years pre- to four years post-diagnosis, stratified by sex and age-group and by group-based trajectory modelling. Associations between trajectory membership, and sociodemographic (sex, age, education, country of birth, type of living area, and family situation) and work disability characteristics at inclusion (whether on disability pension and net days on sickness absence and disability pension) were estimated with chi2 tests and multinomial logistic regressions.
Results: Contrasting trends were observed for earnings and work disability, with differences in pre- and post-diagnosis periods, whereas DI steadily increased over the entire study period. Seven distinct DI trajectory paths were identified: two consistently low trajectories (50.7% of individuals); four increasing trajectories (39.0%); and one decreasing trajectory (10.3%). All included sociodemographic and work disability characteristics were significantly associated with trajectories (p< 0.05). The increasing trajectories were older and had higher proportions of men. University education was less common in the low trajectories. The decreasing and two low trajectories had higher proportions with work disability days.
Conclusions: We observed high diversity of DI development already pre-diagnosis within the cohort aged 25-59 when diagnosed with MS in Sweden. The majority of working-aged people diagnosed with MS experienced increasing or flat DI trajectories, however, a small minority experienced declining financial resources early in the disease course. Sociodemographic and work disability characteristics differed between the trajectories. This diversity is often overlooked when considering socioeconomic outcomes of MS cohorts.
Disclosure: This study was funded by an investigator-initiated trial grant from Biogen. Biogen had the opportunity of a courtesy review of this abstract before submission. This study was also funded by the Swedish Research Council for Health, Working Life and Welfare (2007-1762). Chantelle Murley has a salary paid by an unrestricted research grant from Biogen. Fei Yang is currently employed by PAREXEL, a contract research organisation, to perform commissioned pharmacoepidemiological studies in collaboration with several pharmaceutical companies. Hanna Gyllensten has a salary paid by an unrestricted research grant from Biogen, and is employed part-time by Statfinn & EPID Research, a contract research organisation, to perform commissioned pharmacoepidemiological studies in collaboration with several pharmaceutical companies. Kristina Alexanderson has an unrestricted research grant from Biogen. Emilie Friberg has a salary partly paid by an unrestricted research grant from Biogen.
Abstract: P1036
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Economic burden
Introduction: The economic situation of individuals diagnosed with multiple sclerosis (MS) is relatively unknown, with income suggested to vary with sociodemographic characteristics.
Aim: To identify the diversity of disposable income (DI) trajectories within working-aged people with incident MS, and investigate the associations of sociodemographic characteristics with identified trajectories.
Methods: A population-based cohort study of all 1528 individuals aged 25-59 who had their first MS diagnosis registered in 2008-2009, using data linked from three nationwide Swedish registers. We analysed mean annual DI (benefits and earnings after excluding taxes), earnings, and work disability (net days with reimbursed sickness absence and disability pension benefits) from seven years pre- to four years post-diagnosis, stratified by sex and age-group and by group-based trajectory modelling. Associations between trajectory membership, and sociodemographic (sex, age, education, country of birth, type of living area, and family situation) and work disability characteristics at inclusion (whether on disability pension and net days on sickness absence and disability pension) were estimated with chi2 tests and multinomial logistic regressions.
Results: Contrasting trends were observed for earnings and work disability, with differences in pre- and post-diagnosis periods, whereas DI steadily increased over the entire study period. Seven distinct DI trajectory paths were identified: two consistently low trajectories (50.7% of individuals); four increasing trajectories (39.0%); and one decreasing trajectory (10.3%). All included sociodemographic and work disability characteristics were significantly associated with trajectories (p< 0.05). The increasing trajectories were older and had higher proportions of men. University education was less common in the low trajectories. The decreasing and two low trajectories had higher proportions with work disability days.
Conclusions: We observed high diversity of DI development already pre-diagnosis within the cohort aged 25-59 when diagnosed with MS in Sweden. The majority of working-aged people diagnosed with MS experienced increasing or flat DI trajectories, however, a small minority experienced declining financial resources early in the disease course. Sociodemographic and work disability characteristics differed between the trajectories. This diversity is often overlooked when considering socioeconomic outcomes of MS cohorts.
Disclosure: This study was funded by an investigator-initiated trial grant from Biogen. Biogen had the opportunity of a courtesy review of this abstract before submission. This study was also funded by the Swedish Research Council for Health, Working Life and Welfare (2007-1762). Chantelle Murley has a salary paid by an unrestricted research grant from Biogen. Fei Yang is currently employed by PAREXEL, a contract research organisation, to perform commissioned pharmacoepidemiological studies in collaboration with several pharmaceutical companies. Hanna Gyllensten has a salary paid by an unrestricted research grant from Biogen, and is employed part-time by Statfinn & EPID Research, a contract research organisation, to perform commissioned pharmacoepidemiological studies in collaboration with several pharmaceutical companies. Kristina Alexanderson has an unrestricted research grant from Biogen. Emilie Friberg has a salary partly paid by an unrestricted research grant from Biogen.