Contributions
Abstract: P1002
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Pediatric onset multiple sclerosis (POMS) accounts for about 3-10% of MS cases. Tehran, capital of Iran is one of the regions with highest MS prevalence in Asia. We conducted a survey to estimate the prevalence and familial recurrence of POMS in Tehran.
Method: A population based cross-sectional study was designed to estimate the prevalence of POMS in Tehran since 1999 to 2017 according Iranian MS Society (IMSS) registry system. We collect baseline characteristic information including gender, age, age at disease onset, familial history of MS. Logistic regression analysis was performed to estimate the odds ratio (OR) for individual variable by SPSS.
Results: Totally 1937 POMS patients including 1507 (77.80%) females and 430 (22.20%) males were enrolled in study. The prevalence of POMS was 64.09 in 100,000 in 2017. Mean age at disease onset was 15.96 years old. The average female to male ratio was 3.5:1.This index was 2.02:1 in cases with pre-pubertal onset at 3-12 years old, but it increased to 3.69:1 in 13-18 y/o age groups. (OR =1.82; 95% CI = 1.27- 2.26). Entirely 288 (15.1%) cases with positive familial history of MS (14.6% female and 16.9% male) were found. Among all patients with familial recurrence of MS, the strongest association was seen in second degree relatives (OR＝1.74; 95％ CI ＝1.01−3.01) and in this group the most significant association was seen in maternal aunt/uncle (P value=0.007, OR＝2.63; 95％ CI ＝1.31−5.3).
Conclusion: The prevalence of POMS is high in Tehran. This may be related to the increasing knowledge for diagnosis of MS by physicians. MS risk in females is higher than males and the sex ratio increases dramatically after puberty. There is a significant association between MS risk and positive familial history in the maternal second degree of relatives.
Disclosure: Conflict of interest: None for all authors
Nothing to disclose: for all authors
Source of funding: Tehran University of Medical Sciences
Abstract: P1002
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Pediatric onset multiple sclerosis (POMS) accounts for about 3-10% of MS cases. Tehran, capital of Iran is one of the regions with highest MS prevalence in Asia. We conducted a survey to estimate the prevalence and familial recurrence of POMS in Tehran.
Method: A population based cross-sectional study was designed to estimate the prevalence of POMS in Tehran since 1999 to 2017 according Iranian MS Society (IMSS) registry system. We collect baseline characteristic information including gender, age, age at disease onset, familial history of MS. Logistic regression analysis was performed to estimate the odds ratio (OR) for individual variable by SPSS.
Results: Totally 1937 POMS patients including 1507 (77.80%) females and 430 (22.20%) males were enrolled in study. The prevalence of POMS was 64.09 in 100,000 in 2017. Mean age at disease onset was 15.96 years old. The average female to male ratio was 3.5:1.This index was 2.02:1 in cases with pre-pubertal onset at 3-12 years old, but it increased to 3.69:1 in 13-18 y/o age groups. (OR =1.82; 95% CI = 1.27- 2.26). Entirely 288 (15.1%) cases with positive familial history of MS (14.6% female and 16.9% male) were found. Among all patients with familial recurrence of MS, the strongest association was seen in second degree relatives (OR＝1.74; 95％ CI ＝1.01−3.01) and in this group the most significant association was seen in maternal aunt/uncle (P value=0.007, OR＝2.63; 95％ CI ＝1.31−5.3).
Conclusion: The prevalence of POMS is high in Tehran. This may be related to the increasing knowledge for diagnosis of MS by physicians. MS risk in females is higher than males and the sex ratio increases dramatically after puberty. There is a significant association between MS risk and positive familial history in the maternal second degree of relatives.
Disclosure: Conflict of interest: None for all authors
Nothing to disclose: for all authors
Source of funding: Tehran University of Medical Sciences