Contributions
Abstract: P1001
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Dietary and lifestyle habits are suggested to have a significant effect on the pathogenesis and progression of multiple sclerosis (MS).
Objective: Determine the role of dietary patterns on the early course of MS in Israeli MS patients.
Methods: Relapsing remitting MS patients with disease duration up to 5 years completed a socio demographic questionnaire related to medical, lifestyle, and nutritional aspects, and a 3-day food diary recording all real-life meals and drinks with exact components and weights using their smartphones. Nutrients intake from all food diaries were analyzed based on dedicated software and disease progression variables, e.g. annual relapse rate and neurologic disability by the expanded disability status scale (EDSS) score were assessed during 1 year of follow-up.
To define major dietary patterns, we used factor analysis. Multivariate logistic regression was used to assess the relationship between dietary patterns and progression of MS. Associations between food components intake and dietary supplements and disease progression variables were analyzed by SPSS.
Results: 47 consecutive relapsing remitting MS (RRMS) patients, mean age 33 years, disease duration of 3.6 years, neurological disability by the EDSS score of 1.4, participated in the study. 80% were treated with immunomodulatory drugs.
Mediterranean-like dietary pattern consisting of foods such as fruits and fish and rich in nutrients including fibers, beta-carotene, magnesium and potassium was inversely related to relapse activity (OR = 0.4; 95% CI: 0.19-0.87; p = 0.021). We found a significant difference in the Mediterranean-like dietary pattern factor score between patients who had no relapses compared to patients who had 1 or more relapses during one year of follow up [Mean difference (Md) = 0.61; 95% CI: 0.06-1.16; p = 0.03)]. No correlation was found between dietary patterns and disability progression.
Conclusions: Our findings suggest that dietary patterns that have anti-inflammatory components reduce MS disease activity.
Disclosure: Danyel Chermon: Nothing to disclose. Izhak Levi: Nothing to disclose. Eran Segal: Nothing to disclose. Anat Achiron: I received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Sanofi-Genzyme, Merck/EMD Serono, Roche and Biogen.
Abstract: P1001
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Dietary and lifestyle habits are suggested to have a significant effect on the pathogenesis and progression of multiple sclerosis (MS).
Objective: Determine the role of dietary patterns on the early course of MS in Israeli MS patients.
Methods: Relapsing remitting MS patients with disease duration up to 5 years completed a socio demographic questionnaire related to medical, lifestyle, and nutritional aspects, and a 3-day food diary recording all real-life meals and drinks with exact components and weights using their smartphones. Nutrients intake from all food diaries were analyzed based on dedicated software and disease progression variables, e.g. annual relapse rate and neurologic disability by the expanded disability status scale (EDSS) score were assessed during 1 year of follow-up.
To define major dietary patterns, we used factor analysis. Multivariate logistic regression was used to assess the relationship between dietary patterns and progression of MS. Associations between food components intake and dietary supplements and disease progression variables were analyzed by SPSS.
Results: 47 consecutive relapsing remitting MS (RRMS) patients, mean age 33 years, disease duration of 3.6 years, neurological disability by the EDSS score of 1.4, participated in the study. 80% were treated with immunomodulatory drugs.
Mediterranean-like dietary pattern consisting of foods such as fruits and fish and rich in nutrients including fibers, beta-carotene, magnesium and potassium was inversely related to relapse activity (OR = 0.4; 95% CI: 0.19-0.87; p = 0.021). We found a significant difference in the Mediterranean-like dietary pattern factor score between patients who had no relapses compared to patients who had 1 or more relapses during one year of follow up [Mean difference (Md) = 0.61; 95% CI: 0.06-1.16; p = 0.03)]. No correlation was found between dietary patterns and disability progression.
Conclusions: Our findings suggest that dietary patterns that have anti-inflammatory components reduce MS disease activity.
Disclosure: Danyel Chermon: Nothing to disclose. Izhak Levi: Nothing to disclose. Eran Segal: Nothing to disclose. Anat Achiron: I received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Sanofi-Genzyme, Merck/EMD Serono, Roche and Biogen.