Contributions
Abstract: P985
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Tumefactive multiple sclerosis (TMS) is characterized by the presence of atypical lesions, size >2cm with mass effect, perilesional oedema and/or ring enhancement. It may be the presentation of Multiple Sclerosis (MS), which represents a challenge for the diagnosis, or appear in the evolution of MS already diagnosed.
Aim: To analyze demographic, clinical and radiological features and cognitive outcome in a group of patients with TMS.
Methods: A retrospective study including patients with TMS who were treated at MS clinic. Were registered: age at diagnosis, clinical manifestations, cognitive performance, number and location of tumefactive lesions (TL), presence of contrast enhacement on MRI, biopsies performed and cerebrospinal fluid (CSF) characteristics. Cognitive performance was evaluated using Brief Repeatable Battery of Neuropsychological Tests (BRB-N) and Brief International Cognitive Assessment for MS (BICAMS).
Results: From a total of 358 patients diagnosed with MS according to 2017 McDonald Criteria, 22 patients presented TL. 59% were women. 86% presented TL at the debut of the disease. The mean age at presentation was 29 years. In only 4 patients biopsy was performed. 91% had symptomatic tumefactive lesions, the most common was focal motor deficit (36%). 36% presented atypical symptoms, most frequently encephalopathy (55%). 27% had multiple tumefactive lesions, all supratentorial. 86% had coexistence with typical MS lesions at the presentation. 72% had enhancement of lesions on MRI with complete ring pattern in most cases. OB was positive in 67% of the cases. Of 13 patients evaluated, 70% with at least 1 domains affected was found, visual memory was the most frequent (54%).
Conclusions: There are few series of TMS in the literature. Most of the results are similar to those reported by other authors and will contribute to a better characterization.
It is important to perform the cognitive evaluation of these patients, given the cognitive impairment that we have found.
Disclosure: There are no conflict of interest of these authors for this work.
Abstract: P985
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Tumefactive multiple sclerosis (TMS) is characterized by the presence of atypical lesions, size >2cm with mass effect, perilesional oedema and/or ring enhancement. It may be the presentation of Multiple Sclerosis (MS), which represents a challenge for the diagnosis, or appear in the evolution of MS already diagnosed.
Aim: To analyze demographic, clinical and radiological features and cognitive outcome in a group of patients with TMS.
Methods: A retrospective study including patients with TMS who were treated at MS clinic. Were registered: age at diagnosis, clinical manifestations, cognitive performance, number and location of tumefactive lesions (TL), presence of contrast enhacement on MRI, biopsies performed and cerebrospinal fluid (CSF) characteristics. Cognitive performance was evaluated using Brief Repeatable Battery of Neuropsychological Tests (BRB-N) and Brief International Cognitive Assessment for MS (BICAMS).
Results: From a total of 358 patients diagnosed with MS according to 2017 McDonald Criteria, 22 patients presented TL. 59% were women. 86% presented TL at the debut of the disease. The mean age at presentation was 29 years. In only 4 patients biopsy was performed. 91% had symptomatic tumefactive lesions, the most common was focal motor deficit (36%). 36% presented atypical symptoms, most frequently encephalopathy (55%). 27% had multiple tumefactive lesions, all supratentorial. 86% had coexistence with typical MS lesions at the presentation. 72% had enhancement of lesions on MRI with complete ring pattern in most cases. OB was positive in 67% of the cases. Of 13 patients evaluated, 70% with at least 1 domains affected was found, visual memory was the most frequent (54%).
Conclusions: There are few series of TMS in the literature. Most of the results are similar to those reported by other authors and will contribute to a better characterization.
It is important to perform the cognitive evaluation of these patients, given the cognitive impairment that we have found.
Disclosure: There are no conflict of interest of these authors for this work.