Contributions
Abstract: P962
Type: Poster Sessions
Abstract Category: Therapy - Others
Background: Respiratory infections (bronchopneumonia) are one of the most common causes of death in multiple sclerosis (MS). An effective cough is essential for clearing respiratory secretions and keeping the airways free of foreign material. Cough efficacy may be impaired because of respiratory muscle weakness, which is frequently reported already in individuals with mild to moderate MS.
Objective: This study aimed to determine whether a combined aerobic-resistance circuit training is effective for improving strength of respiratory muscles in individuals with mild to moderate MS.
Method: A total of 21 participants (20 females and 1 male) with mild to moderate MS were enrolled. Participants completed 12 weeks of combined aerobic-resistance circuit training (1hour/ 2 times per week). Pre- and post-training measures included maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP) and subjective evaluation of dyspnea.
Results: One individual withdrew from the study after 2 months due to MS relaps. Therefore, a total of 20 participants (mean ± SD: 47 ± 10 years; 2,6 ± 1,5 EDSS; 12 ± 9 years from diagnosis) completed 12 weeks of training protocol. The percentage of baseline MIP predicted values ranged from 42% to 149% (mean ± SD, 86 ± 30%) and from 45% to 133% (mean ± SD, 99 ± 22%) for baseline MEP values. There were no significant differences between pre- and post-training MIP (mean ± SD pre-/post-treatment: 64 ± 8 cmH2O/ 63 ± 18 cmH2O, p = 0,55) or MEP values (mean ± SD pre-/post-treatment: 95 ± 17 cmH2O/ 96 ± 12 cmH2O, p = 0,84). No significant changes occurred in subjective evaluation of dyspnea.
Conclusions: Our pilot results suggest that combined aerobic-resistance circuit training does not enhance strength of respiratory muscles and has no effect on subjective evaluation of dyspnea in individuals with mild to moderate MS. Thus, different methods must be implemented in respiratory muscle strength training. However, further work in this topic is needed.
Disclosure: Martin Srp: nothing to disclose. Klára Novotná: has received personal compensation for consulting and speaking for Merck, Novartis, Roche, and Teva. Eva Kubala Havrdová: has received personal compensation for consulting and speaking for Actelion, Biogen, Celgene, Merck, Novartis, Sanofi, Roche, and Teva, and is supported by Czech Ministry of Education, project PROGRES Q27/LF1. Martina Hoskovcová: nothing to disclose.
Abstract: P962
Type: Poster Sessions
Abstract Category: Therapy - Others
Background: Respiratory infections (bronchopneumonia) are one of the most common causes of death in multiple sclerosis (MS). An effective cough is essential for clearing respiratory secretions and keeping the airways free of foreign material. Cough efficacy may be impaired because of respiratory muscle weakness, which is frequently reported already in individuals with mild to moderate MS.
Objective: This study aimed to determine whether a combined aerobic-resistance circuit training is effective for improving strength of respiratory muscles in individuals with mild to moderate MS.
Method: A total of 21 participants (20 females and 1 male) with mild to moderate MS were enrolled. Participants completed 12 weeks of combined aerobic-resistance circuit training (1hour/ 2 times per week). Pre- and post-training measures included maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP) and subjective evaluation of dyspnea.
Results: One individual withdrew from the study after 2 months due to MS relaps. Therefore, a total of 20 participants (mean ± SD: 47 ± 10 years; 2,6 ± 1,5 EDSS; 12 ± 9 years from diagnosis) completed 12 weeks of training protocol. The percentage of baseline MIP predicted values ranged from 42% to 149% (mean ± SD, 86 ± 30%) and from 45% to 133% (mean ± SD, 99 ± 22%) for baseline MEP values. There were no significant differences between pre- and post-training MIP (mean ± SD pre-/post-treatment: 64 ± 8 cmH2O/ 63 ± 18 cmH2O, p = 0,55) or MEP values (mean ± SD pre-/post-treatment: 95 ± 17 cmH2O/ 96 ± 12 cmH2O, p = 0,84). No significant changes occurred in subjective evaluation of dyspnea.
Conclusions: Our pilot results suggest that combined aerobic-resistance circuit training does not enhance strength of respiratory muscles and has no effect on subjective evaluation of dyspnea in individuals with mild to moderate MS. Thus, different methods must be implemented in respiratory muscle strength training. However, further work in this topic is needed.
Disclosure: Martin Srp: nothing to disclose. Klára Novotná: has received personal compensation for consulting and speaking for Merck, Novartis, Roche, and Teva. Eva Kubala Havrdová: has received personal compensation for consulting and speaking for Actelion, Biogen, Celgene, Merck, Novartis, Sanofi, Roche, and Teva, and is supported by Czech Ministry of Education, project PROGRES Q27/LF1. Martina Hoskovcová: nothing to disclose.