Contributions
Abstract: P847
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: It has been shown that the vestibular evoked myogenic potentials (VEMP) are able to detect vestibular system involvement in people with clinically isolated syndrome (pwCIS), regardless of the MRI results. The aim of this study was to investigate the evolution of vestibular system involvement measured by VEMPs in pwCIS over two-year follow-up.
Methods: In 121 pwCIS (85 females, mean age 32.15±8.74, median EDSS 1 (0 - 3.5)) ocular VEMP (oVEMP) and cervical VEMP (cVEMP) were performed at baseline and 84 after two-year follow-up. The following VEMP components were analyzed: peak-to-peak n10-p13 amplitude, n10 and p13 latencies for oVEMP, and normalized p13-n23 amplitude, p13 and n23 latencies for cVEMP. For each patient, the VEMP score was calculated as the sum of four four-graded scores derived from the evaluation of each VEMP. Similarly, oVEMP and cVEMP scores were calculated.
Results: Baseline median VEMP score was 4 (range 0-12) (median oVEMP score 2 (0-6) and median cVEMP score 1 (0-6)). Median VEMP score after two years of follow-up was 4 (range 0-12) (median oVEMP score 2 (0-6) and median cVEMP score 2 (0-6)). This worsening of cVEMP score after two-year follow-up was statistically significant, p=0.022.
Out of 84 patients with all data available for analysis, conduction block on at least one cVEMP response was present in 3 patients at baseline and 9 patients after two years (p=0.109) and in 13 patients at baseline and 36 patients after two years on at least one oVEMP response (p< 0.001). Conduction block on at least one VEMP response was present in 15 patients at baseline and 36 patients after two years (p=0.001).
Conclusion: Substantial proportion of pwCIS experience worsening of VEMP over 24 months of follow-up.
Disclosure: Barbara Barun: nothing to disclose.
Luka Crnošija: nothing to disclose.
Ivan Adamec: nothing to disclose.
Tereza Gabelić: nothing to disclose.
Berislav Ruška: nothing to disclose.
Magdalena Krbot Skorić: nothing to disclose.
Mario Habek: nothing to disclose.
Abstract: P847
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: It has been shown that the vestibular evoked myogenic potentials (VEMP) are able to detect vestibular system involvement in people with clinically isolated syndrome (pwCIS), regardless of the MRI results. The aim of this study was to investigate the evolution of vestibular system involvement measured by VEMPs in pwCIS over two-year follow-up.
Methods: In 121 pwCIS (85 females, mean age 32.15±8.74, median EDSS 1 (0 - 3.5)) ocular VEMP (oVEMP) and cervical VEMP (cVEMP) were performed at baseline and 84 after two-year follow-up. The following VEMP components were analyzed: peak-to-peak n10-p13 amplitude, n10 and p13 latencies for oVEMP, and normalized p13-n23 amplitude, p13 and n23 latencies for cVEMP. For each patient, the VEMP score was calculated as the sum of four four-graded scores derived from the evaluation of each VEMP. Similarly, oVEMP and cVEMP scores were calculated.
Results: Baseline median VEMP score was 4 (range 0-12) (median oVEMP score 2 (0-6) and median cVEMP score 1 (0-6)). Median VEMP score after two years of follow-up was 4 (range 0-12) (median oVEMP score 2 (0-6) and median cVEMP score 2 (0-6)). This worsening of cVEMP score after two-year follow-up was statistically significant, p=0.022.
Out of 84 patients with all data available for analysis, conduction block on at least one cVEMP response was present in 3 patients at baseline and 9 patients after two years (p=0.109) and in 13 patients at baseline and 36 patients after two years on at least one oVEMP response (p< 0.001). Conduction block on at least one VEMP response was present in 15 patients at baseline and 36 patients after two years (p=0.001).
Conclusion: Substantial proportion of pwCIS experience worsening of VEMP over 24 months of follow-up.
Disclosure: Barbara Barun: nothing to disclose.
Luka Crnošija: nothing to disclose.
Ivan Adamec: nothing to disclose.
Tereza Gabelić: nothing to disclose.
Berislav Ruška: nothing to disclose.
Magdalena Krbot Skorić: nothing to disclose.
Mario Habek: nothing to disclose.