Contributions
Abstract: P845
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Cognitive impairment (CI) affects 40-65% of patients with multiple sclerosis (MS) and constitutes one of the main causes of disability. Although cognitive rehabilitation (CR) has shown efficacy in attention and memory, there is insufficient evidence to generate clinical practice guidelines. Telematic CR (TCR) reduces costs and interferes less in patient's daily activities.
Objective: To analyse the efficacy of mixed cognitive stimulation (TCR and face-to-face) in the CI of patients with relapsing-remitting MS (RRMS).
Material and methods: Longitudinal, prospective, randomized and controlled study in a cohort of RRMS patients (Mc-Donald 2010 criteria), with EDSS ≤ 6.0, minimental state ≥ 26, Multiple Sclerosis Neuropychological Screening Questionnaire (MSNQ)>27 and/or Symbol Digit Modality Test (SDMT) < 42 (raw score). Two groups were differentiated: with CR and without CR. CR was task-specific (processing speed -PS-, memory, attention and executive functions) and was performed in 24 TCR sessions and 12 face-to-face sessions. The Unobrain computer program was used. All patients were evaluated at the beginning and at 3 months after treatment with an extensive battery that included PS, working memory, episodic memory, attention and executive functions. The psychosocial impact was evaluated by MSNQ. Nonparametric tests were used to evaluate the changes in cognition at 3 months with respect to baseline intra and inter-groups.
Results: Fifty-one RRMS patients were included, 34 received CR and 16 no. There were no differences in baseline CI between groups. Patients realized 100% of TCR sessions and 90% of face-to-face sessions. CR improved performance in almost all cognitive functions intra-group, compared to controls, only the effect remains in PS (P = 0.023) and episodic memory (learning curve, p = 0.027).
Conclusions: Mixed CR showed in our patients an excellent adherence to the computer program and a clear short-term benefit in PS and episodic memory.
Disclosure: Authors declare not having conflicts of interest respect to this work.
We report all possible disclosures to be thorough:
Y. Aladro. had received speakers' honoraria from Novartis, Biogen Idec, Teva and Merck Serono; serves as a consultant and scientific advisory boards for some Pharmaceutical Industries (Teva, Novartis, Biogen Idec, Sanofi Genzyme and Merck Serono).
Marta Cerezo receive support to investigate from Novartis and Teva.
This work has a funding of Mutua Madrileña Foundation.
Abstract: P845
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Introduction: Cognitive impairment (CI) affects 40-65% of patients with multiple sclerosis (MS) and constitutes one of the main causes of disability. Although cognitive rehabilitation (CR) has shown efficacy in attention and memory, there is insufficient evidence to generate clinical practice guidelines. Telematic CR (TCR) reduces costs and interferes less in patient's daily activities.
Objective: To analyse the efficacy of mixed cognitive stimulation (TCR and face-to-face) in the CI of patients with relapsing-remitting MS (RRMS).
Material and methods: Longitudinal, prospective, randomized and controlled study in a cohort of RRMS patients (Mc-Donald 2010 criteria), with EDSS ≤ 6.0, minimental state ≥ 26, Multiple Sclerosis Neuropychological Screening Questionnaire (MSNQ)>27 and/or Symbol Digit Modality Test (SDMT) < 42 (raw score). Two groups were differentiated: with CR and without CR. CR was task-specific (processing speed -PS-, memory, attention and executive functions) and was performed in 24 TCR sessions and 12 face-to-face sessions. The Unobrain computer program was used. All patients were evaluated at the beginning and at 3 months after treatment with an extensive battery that included PS, working memory, episodic memory, attention and executive functions. The psychosocial impact was evaluated by MSNQ. Nonparametric tests were used to evaluate the changes in cognition at 3 months with respect to baseline intra and inter-groups.
Results: Fifty-one RRMS patients were included, 34 received CR and 16 no. There were no differences in baseline CI between groups. Patients realized 100% of TCR sessions and 90% of face-to-face sessions. CR improved performance in almost all cognitive functions intra-group, compared to controls, only the effect remains in PS (P = 0.023) and episodic memory (learning curve, p = 0.027).
Conclusions: Mixed CR showed in our patients an excellent adherence to the computer program and a clear short-term benefit in PS and episodic memory.
Disclosure: Authors declare not having conflicts of interest respect to this work.
We report all possible disclosures to be thorough:
Y. Aladro. had received speakers' honoraria from Novartis, Biogen Idec, Teva and Merck Serono; serves as a consultant and scientific advisory boards for some Pharmaceutical Industries (Teva, Novartis, Biogen Idec, Sanofi Genzyme and Merck Serono).
Marta Cerezo receive support to investigate from Novartis and Teva.
This work has a funding of Mutua Madrileña Foundation.